86227-47-6

• 常用中文名：全顺-5,8,11,14,17-二十碳五烯酸乙酯
• 常用英文名：Eicosapentaenoic acid (ethyl ester)
• CAS号：86227-47-6
• 分子式：C₂₂H₃₄O₂
• 分子量：330.504
• 相关类别： 化学试剂 有机试剂 酯类 乙酯类化合物
• 发布时间：2018-08-27 19:50:50
• 更新时间：2024-01-10 17:24:35
• Eicosapentaenoic acid ethyl ester (AMR-101) 是一种 ω-3 脂肪酸剂。

名称

• 中文名: 顺-二十碳五烯酸乙酯
• 英文名: ethyl (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate
• 中文别名: cis-5,8,11,14,17-二十碳五烯酸乙酯; 顺-5,8,11,14,17-十二碳五烯酸乙酯
• 英文别名: Epadel; 5,8,11,14,17-Eicosapentaenoic acid, ethyl ester, (all-Z)-; all-cis-5,8,11,14,17-Eicosapentaenoic Acid Ethyl Ester; Eicosapentaenoic acid-D5 ethyl ester; Ethyl icosapentate; ALL CIS-5,8,11,14,17-EICOSAPENTAENOIC ACID ETHYL ESTER; E-EPA; AMR 101; ethyl icosapentaenoate; ethyl (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate; (Z,Z,Z,Z,Z)-5,8,11,14,17-EICOSAPENTAENOIC ACID ETHYL ESTER; 5,8,11,14,17-Eicosapentaenoic acid, ethyl ester, (5Z,8Z,11Z,14Z,17Z)-; Ethyl all cis-5,8,11,14,17-Eicosapentaenoate; Ethyl all cis-5,8,11,14,17-Icosapentaenoate; ethyl (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate; ethyl all-cis-5,8,11,14,17-icosapentaenoate; ethyl eicosapentaenoate; Ethyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate; EICOSAPENTAENOIC ACID ETHYL ESTER; Timnodonic acid ethyl ester; (5Z,8Z,11Z,14Z,17Z)-Eicosapetaenoic acid ethyl ester; ALL CIS-5,8,11,14,17-EICOSAPENTANOIC ACID ETHYL ESTER; Ethyl (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-icosapentaenoate; CIS-5,8,11,14,17-EICOSAPENTAENOIC ACID ETHYL ESTER; Ethyl (all cis)-5,8,11,14,17-icosapentaenoate; (all-Z)-5,8,11,14,17-Eicosapentaenoic acid ethyl ester; Eicosapentaenoic Acid ethyl este; AMR-101; Eicosapentaenoic acid, ethyl ester; Vascepa; OMEGA-3-ACID ESTERS (EPA shown); Ethyl eicosapentaenoic acid; Icosapent ethyl; MFCD00673476; Eicosapentaenoic acid (ethyl ester)

物化性质

• 密度: 0.9±0.1 g/cm3
• 沸点: 417.0±34.0 °C at 760 mmHg
• 分子式: C₂₂H₃₄O₂
• 分子量: 330.504
• 闪点: 103.1±24.0 °C
• 精确质量: 330.255890
• PSA: 26.30000
• LogP: 7.32
• 外观性状: 液体;Colorless to Almost colorless clear liquid
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.496
• 储存条件:

  冷藏

• 水溶解性: 水溶性：不溶
• 计算化学:

  1.疏水参数计算参考值（XlogP）:6.3

  2.氢键供体数量:0

  3.氢键受体数量:2

  4.可旋转化学键数量:15

  5.互变异构体数量:无

  6.拓扑分子极性表面积26.3

  7.重原子数量:24

  8.表面电荷:0

  9.复杂度:425

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:5

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：未确定

  2. 密度（g/mL25 ºC）：0，91

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC0.35mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（正辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: Eicosapentaenoic acid ethyl ester (AMR-101) 是一种 ω-3 脂肪酸剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Jacobson TA. A new pure ω-3 eicosapentaenoic acid ethyl ester (AMR101) for the management of hypertriglyceridemia: the MARINE trial. Expert Rev Cardiovasc Ther. 2012 Jun;10(6):687-695.

  [2]. Bays HE, et al. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from theMulti-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension[MARINE] trial). Am J Cardiol. 2011 Sep 1;108(5):682-690.

MSDS

Ethyl all cis-5,8,11,14,17-Eicosapentaenoate (stabilized Revision number: 6 with Tocopherols) SAFETY DATA SHEET Section1. IDENTIFICATION Product name:Ethyl all cis-5,8,11,14,17-Eicosapentaenoate (stabilized with Tocopherols) Revision number:6 Section2. HAZARDS IDENTIFICATION GHS classification PHYSICAL HAZARDSNot classified Not classified HEALTH HAZARDS ENVIRONMENTAL HAZARDSNot classified GHS label elements, including precautionary statements Pictograms or hazard symbolsNone Signal wordNo signal word Hazard statementsNone Precautionary statements:None Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substance Substance/mixture: Components:Ethyl all cis-5,8,11,14,17-Eicosapentaenoate (stabilized with Tocopherols) >65.0%(GC) Percent: CAS Number:86227-47-6 all cis-5,8,11,14,17-Eicosapentaenoic Acid Ethyl Ester (stabilized with Tocopherols) , Synonyms: EPA Ethyl Ester (stabilized with Tocopherols) , Ethyl all cis-5,8,11,14,17- Icosapentaenoate (stabilized with Tocopherols) Chemical Formula:C22H34O2 Section4. FIRST AID MEASURES Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell. Skin contact:Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. If skin irritation or rash occurs: Get medical advice/attention. Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Get medical advice/attention if you feel unwell. Rinse mouth. Ingestion: Protection of first-aiders:A rescuer should wear personal protective equipment, such as rubber gloves and air- tight goggles. Section5. FIRE-FIGHTING MEASURES Dry chemical, foam, carbon dioxide. Suitable extinguishing media: Ethyl all cis-5,8,11,14,17-Eicosapentaenoate (stabilized with Tocopherols) Section5. FIRE-FIGHTING MEASURES Unsuitable extinguishing Water (It may scatter and spread fire.) media: Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Remove movable containers if safe to do so. Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment. equipment for firefighters: Section6. ACCIDENTAL RELEASE MEASURES Use personal protective equipment. Keep people away from and upwind of spill/leak. Personal precautions, protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled emergency procedures: around the leakage area by roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Absorb spilled material in a suitable absorbent (e.g. rag, dry sand, earth, saw-dust). containment and cleaning In case of large amount of spillage, contain a spill by bunding. Adhered or collected up: material should be promptly disposed of, in accordance with appropriate laws and regulations. Section7. HANDLING AND STORAGE Precautions for safe handling Technical measures:Handling is performed in a well ventilated place. Wear suitable protective equipment. Prevent generation of vapour or mist. Wash hands and face thoroughly after handling. Use a ventilation, local exhaust if vapour or aerosol will be generated. Advice on safe handling: Avoid contact with skin, eyes and clothing. Conditions for safe storage, including any incompatibilities Storage conditions:Keep container tightly closed. Store in a refrigerator. Store under inert gas. Store away from incompatible materials such as oxidizing agents. Heat-sensitive, Air-sensitive Packaging material:Comply with laws. Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION Install a closed system or local exhaust as possible so that workers should not be Engineering controls: exposed directly. Also install safety shower and eye bath. Personal protective equipment Respiratory protection: Vapor respirator. Follow local and national regulations. Protective gloves. Hand protection: Eye protection:Safety glasses. A face-shield, if the situation requires. Skin and body protection: Protective clothing. Protective boots, if the situation requires. Section9. PHYSICAL AND CHEMICAL PROPERTIES Physical state (20°C):Liquid Form:Clear Colorless - Yellow Colour: Odour:No data available pH: No data available Melting point/freezing point:No data available No data available Boiling point/range: Flash point:No data available Flammability or explosive limits: Lower:No data available Upper:No data available Ethyl all cis-5,8,11,14,17-Eicosapentaenoate (stabilized with Tocopherols) Section9. PHYSICAL AND CHEMICAL PROPERTIES Relative density:0.91 Solubility(ies): [Water]No data available No data available [Other solvents] Section10. STABILITY AND REACTIVITY Chemical stability:Stable under proper conditions. Possibility of hazardous No special reactivity has been reported. reactions: Incompatible materials: Oxidizing agents Hazardous decomposition Carbon monoxide, Carbon dioxide products: Section11. TOXICOLOGICAL INFORMATION No data available Acute Toxicity: Skin corrosion/irritation: No data available No data available Serious eye damage/irritation: Germ cell mutagenicity: No data available Carcinogenicity: No data available IARC = NTP =No data available No data available Reproductive toxicity: Section12. ECOLOGICAL INFORMATION Ecotoxicity: Fish:No data available Crustacea:No data available Algae:No data available Persistence / degradability: No data available BioaccumulativeNo data available potential(BCF): Mobility in soil Log Pow:No data available Soil adsorption (Koc):No data available Henry's LawNo data available constant(PaM3/mol): Section13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section14. TRANSPORT INFORMATION Hazards Class:Does not correspond to the classification standard of the United Nations UN-No:Not listed Section15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002 and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed. Ethyl all cis-5,8,11,14,17-Eicosapentaenoate (stabilized with Tocopherols) SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2916190090

合成路线

10417-94-4 64-17-5 ~64% 86227-47-6

文献：Takahashi, Yoshinori; Tanaka, Kaori; Murakami, Mototake; Kawanari, Masami; Kawasaki, Yoshihiro; et al. Bioscience, Biotechnology, and Biochemistry, 1995 , vol. 59, # 5 p. 809 - 812

10417-94-4 64-17-5 105-58-8 ~99% 86227-47-6

文献：Morrone; D'Antona; Biondi; Lambusta; Nicolosi Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 173 - 176

10417-94-4 64-17-5 122-51-0 ~98% 86227-47-6

文献：Morrone; D'Antona; Biondi; Lambusta; Nicolosi Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 173 - 176

上下游产品

上游产品  4
10417-94-4 64-17-5 105-58-8 122-51-0
下游产品  6
108698-02-8 112-85-6 105-54-4 99660-94-3
10417-94-4 6217-54-5

海关

海关编码	2916190090
中文概述	2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%