135729-61-2

• 常用中文名：帕洛诺司琼
• 常用英文名：Palonosetron
• CAS号：135729-61-2
• 分子式：C₁₉H₂₄N₂O
• 分子量：296.407
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-07-25 18:02:37
• 更新时间：2025-08-25 22:54:45
• Palonosetron是5-HT3受体拮抗剂,可作用于化疗引起的恶心和呕吐。

名称

• 中文名: 帕洛诺司琼
• 英文名: palonosetron
• 英文别名: (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one; (S)-(S)-2-(1-Aza-bicyclo[2.2.2]oct-; 3-yl)-2,3,3a,4,5,6-hexahydro-benzo[; de]isoquinolin-1-one; (3aS)-2-((3S)-1-Azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one; 1H-Benz[de]isoquinolin-1-one, 2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, (3aS)-; Aloxi; 2-Qhbiqo; (3aS)-2,3,3a,4,5,6-Hexahydro-2-[(3S)-3-quinuclidinyl]-1H-benz[de]isoquinolin-1-one; 1H-Benz[de]isoquinolin-1-one, 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-, [S-(R*,R*)]-, hydrochloride; Palonosetron

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 470.4±45.0 °C at 760 mmHg
• 分子式: C₁₉H₂₄N₂O
• 分子量: 296.407
• 闪点: 209.5±21.1 °C
• 精确质量: 296.188873
• PSA: 23.55000
• LogP: 2.61
• 外观性状: 粉末
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.646
• 储存条件: -20℃

生物活性

• 描述: Palonosetron是5-HT3受体拮抗剂,可作用于化疗引起的恶心和呕吐。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Celio L, Agustoni F, Testa I, Dotti K, De Braud F.Palonosetron: an evidence-based choice in prevention of nausea and vomiting induced by moderately emetogenic chemotherapy.Tumori. 2012 May;98(3):279-86.

  [2]. Blazer M, Phillips G, Reardon J, Efries D, Smith Y, Weatherby L, Juergens K, Rose J, Griffith N, Bekaii-Saab T.Antiemetic control with palonosetron in patients with gastrointestinal cancer receiving a fluoropyrimidine-based regimen in addition to either i

  [3]. Dogan U, Yavas G, Tekinalp M, Yavas C, Ata OY, Ozdemir K.Evaluation of the acute effect of palonosetron on transmural dispersion of myocardial repolarization.Eur Rev Med Pharmacol Sci. 2012 Apr;16(4):462-8.

  [4]. Jin Y, Sun W, Gu D, Yang J, Xu Z, Chen J.Comparative efficacy and safety of palonosetron with the first 5-HT3 receptor antagonists for the chemotherapy-induced nausea and vomiting: a meta-analysis.Eur J Cancer Care (Engl). 2012 Apr 22.

  [5]. Clark, Robin D.; Miller, Aaron B.; Berger, Jacob; Repke, David B.; Weinhardt, Klaus K.; Kowalczyk, Bruce A.; Eglen, Richard M.; Bonhaus, Douglas W.; Lee, Chi Ho; et al.2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformati