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26098-04-4

26098-04-4结构式

常用中文名：庆大霉素C1a
常用英文名：gentamycin C1a
CAS号：26098-04-4
分子式：C₁₉H₃₉N₅O₇
分子量：449.54200
相关类别：信号通路抗感染细菌
发布时间：2018-09-06 09:03:21
更新时间：2024-01-02 22:41:19
庆大霉素C1a是半合成抗生素阿替米辛的前体,具有抗菌活性。庆大霉素C1a是庆大霉素复合物的主要成分[1][2]。

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中文名	庆大霉素C1a
英文名	gentamycin C1a
英文别名	Geneticin C1a Gentamicin C1a Pentaacetate Salt GentaMycin C1a Acetate Gentamycin C1a GentaMicin C3 Acetate Gentamisin C3 Gentamicin D Gentamicin C1a GentaMicin D Acetate Gentamicin C3

描述	庆大霉素C1a是半合成抗生素阿替米辛的前体,具有抗菌活性。庆大霉素C1a是庆大霉素复合物的主要成分[1][2]。
相关类别	研究领域 >> 感染信号通路 >> 抗感染 >> 细菌
体外研究	庆大霉素C1a抑制大肠杆菌,P。绿脓杆菌和金黄色葡萄球菌活性,国际50值为 1 mg/mL[2]庆大霉素C1a(2mM,48小时)对 OC-k3型细胞活力没有影响[2].
体内研究	庆大霉素C1a(4mg/kg静脉推注剂量,单次) 在比格犬体内的平均停留时间为 84分钟,氯值为 1.81 mL/min/kg[3]
参考文献	[1]. Li D, et al. Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res. 2013 Jun 12;168(5):263-7. [2]. Ishikawa M, et al. Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Sci Rep. 2019 Feb 20;9(1):2410. [3]. Isoherranen N, et al. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44(6):1443-7.

密度	1.36g/cm3
沸点	675.2ºC at 760 mmHg
熔点	102-108ºC
分子式	C₁₉H₃₉N₅O₇
分子量	449.54200
闪点	362.1ºC
精确质量	449.28500
PSA	213.72000
蒸汽压	3.97E-21mmHg at 25°C
折射率	1.603
储存条件	-20°C，干燥

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK2290000

CHEMICAL NAME :: D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopy ranosyl-(1-6)-O-(2,6- diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyrano syl-(1-4))-2-deoxy-

CAS REGISTRY NUMBER :: 26098-04-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H39-N5-O7

MOLECULAR WEIGHT :: 449.63

WISWESSER LINE NOTATION :: T6OTJ CQ DM1 EQ E1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CZ F1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,239,1977

危害码 (欧洲)	Xn
海关编码	3004909090

32385-11-8结构式

32385-11-8

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26098-04-4结构式

26098-04-4

52093-21-7结构式

52093-21-7

文献：Agricultural and Biological Chemistry, , vol. 46, # 2 p. 515 - 522

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海关编码	3004909090