41933-33-9

41933-33-9结构式

常用中文名：2-苄基-4,5-二氯哒嗪-3-酮
常用英文名：2-Benzyl-4,5-dichloropyridazine-3(2H)-one
CAS号：41933-33-9
分子式：C₁₁H₈Cl₂N₂O
分子量：255.10000
相关类别：医药中间体杂环化合物哒嗪类化合物
发布时间：2018-11-28 17:34:43
更新时间：2024-01-20 19:09:49
EcDsbB-IN-9(化合物9)是一种有效的大肠杆菌DsbB(EcDsbB)抑制剂,IC50为1.7μM,Ki为46 nM[1]。

中文名	4,5-二氯-2-苄基-3(2H)-哒嗪
英文名	2-Benzyl-4,5-dichloropyridazin-3(2H)-one
中文别名	2-苄基-4,5-二氯哒嗪-3(2H)-酮 2-苄基-4,5-二氯哒嗪-3-酮 2-苄基-4,5-二氯-2,3-二氢吡嗪-3-酮
英文别名	2-benzyl-4,5-dichloropyridazin-3-one

描述	EcDsbB-IN-9(化合物9)是一种有效的大肠杆菌DsbB(EcDsbB)抑制剂,IC50为1.7μM,Ki为46 nM[1]。
相关类别	研究领域 >> 感染信号通路 >> 其他 >> 其他
靶点	IC50: 1.7 μM (EcDsbB)[1] Ki: 46 nM (EcDsbB)[1]
体外研究	EcDsbB-IN-9(化合物9)(0-100μM)导致还原的DsbA(EcDsbB底物)积聚,并以8.5±0.6μM的IC50抑制DsbA的氧化[1]。

密度	1.38g/cm3
沸点	338ºC at 760 mmHg
熔点	87ºC
分子式	C₁₁H₈Cl₂N₂O
分子量	255.10000
闪点	158.2ºC
精确质量	254.00100
PSA	34.89000
LogP	2.59840
折射率	1.626
储存条件	室温，干燥

Name:	2-Benzyl-4 5-dichloro-2 3-dihydropyridazin-3-one 97% Material Safety Data Sheet
Synonym:	2-Benzyl-4,5-dichloropyridazine-3(2H)-on
CAS:	41933-33-9

Section 1 - Chemical Product MSDS Name:2-Benzyl-4 5-dichloro-2 3-dihydropyridazin-3-one 97% Material Safety Data Sheet
Synonym:2-Benzyl-4,5-dichloropyridazine-3(2H)-on

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
41933-33-9	2-Benzyl-4,5-dichloro-2,3-dihydropyrid	97%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 41933-33-9: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: orange
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 87 - 89 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C11H8Cl2N2O
Molecular Weight: 255

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 41933-33-9 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Benzyl-4,5-dichloro-2,3-dihydropyridazin-3-one - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 41933-33-9: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 41933-33-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 41933-33-9 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

危害码 (欧洲)	Xi:Irritant;
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S26-S37/39
海关编码	2933990090

932-22-9

100-39-0

~95%

41933-33-9

文献：Ewing, William R.; Zhu, Yeheng; Ellsworth, Bruce A. Patent: US2006/287323 A1, 2006 ; Location in patent: Page/Page column 12 ; US 20060287323 A1

932-22-9

100-44-7

~92%

41933-33-9

文献：Cho, Su-Dong; Kweon, Deok-Heon; Kang, Young-Jin; Chung, Hyun-A.; Yoon, Yong-Jin Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 3 p. 601 - 605

上游产品 3
932-22-9 100-39-0 100-44-7
下游产品 4
77541-65-2 825633-93-0 825634-03-5 40890-47-9

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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