6703-27-1

• 常用中文名：6-O-Acetyl Codeine
• 常用英文名：6-O-Acetyl Codeine
• CAS号：6703-27-1
• 分子式：C₂₀H₂₃NO₄
• 分子量：341.40100
• 发布时间：2017-04-25 17:35:24
• 更新时间：2025-08-25 10:07:44

名称

• 英文名: 6-O-Acetyl Codeine
• 英文别名: [(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl] acetate

物化性质

• 密度: 1.3 g/cm3
• 沸点: 461.2ºC at 760 mmHg
• 熔点: 132-134ºC
• 分子式: C₂₀H₂₃NO₄
• 分子量: 341.40100
• 闪点: 232.7ºC
• 精确质量: 341.16300
• PSA: 48.00000
• LogP: 2.00980
• 外观性状: 白色晶体
• 折射率: 1.627

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QD0960000 CHEMICAL NAME : Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-, acetate CAS REGISTRY NUMBER : 6703-27-1 LAST UPDATED : 199106 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C20-H23-N-O4 MOLECULAR WEIGHT : 341.44 WISWESSER LINE NOTATION : T B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FOV1 JO1 P1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 99 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 28ZNAE "Public Health Reports, Supplement." (Washington, DC) Volume(issue)/page/year: 138,10,1938

安全

• 符号: GHS02, GHS07
• 信号词: Danger
• 危害声明: H225-H302 + H312 + H332-H319
• 警示性声明: P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235
• 危险品运输编码: UN 1648 3 / PGII

合成路线

108-24-7 467-13-0 ~84% 6703-27-1

文献：EURO-CELTIQUE S.A. Patent: WO2005/77957 A2, 2005 ; Location in patent: Page/Page column 33-34 ;

52-28-8 108-24-7 ~99% 6703-27-1

文献：Antonilli, Letizia; Togna, Anna Rita; Sabatini, Giovanna; Venditti, Alessandro; Guarcini, Laura; Togna, Giuseppina I.; Nicoletti, Rosario; Sanasi, Filomena; Bianco, Armandodoriano; Nencini, Paolo Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 24 p. 7955 - 7963

467-13-0 ~% 6703-27-1

文献：US5869669 A1, ;

76-57-3 ~% 125218-18-0 6703-27-1

文献：Tetrahedron Letters, , vol. 30, # 11 p. 1381 - 1382

108-24-7 76-57-3 ~98% 6703-27-1

文献：Cheng, Chen-Yu; Hsin, Ling-Wei; Lin, Yen-Pin; Tao, Pao-Luh; Jong, Ting-Ting Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 1 p. 73 - 80

上下游产品

上游产品  4
108-24-7 467-13-0 52-28-8 76-57-3
下游产品  1
508-54-3