34707-92-1

• 常用中文名：氯丝菌素
• 常用英文名：chlorothricin
• CAS号：34707-92-1
• 分子式：C₅₀H₆₃ClO₁₆
• 分子量：955.479
• 相关类别： 研究领域 感染
• 发布时间：2018-09-29 17:56:31
• 更新时间：2025-08-23 14:52:20
• 氯菊酯是一种抗生素,是猪心苹果酸脱氢酶的抑制剂[1]。

名称

• 中文名: 氯丝菌素
• 英文名: Chlorothricin
• 英文别名: Diuresal; (1S,3R,6R,7E,13R,16S,17S,21R,22R)-17-({4-O-[3-O-(3-Chloro-6-methoxy-2-methylbenzoyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]-2,6-dideoxy-β-D-arabino-hexopyranosyl}oxy)-28-hydroxy-3,22-dimethyl-23,26-dioxo-24,27-dioxapentacyclo[23.2.1.0.0.0]octacosa-4,7,14,25(28)-tetraene-4-carboxylic acid; Chlorothiazid; Chlotride; chlorothiazide; Chlorthiazide; (1S,3R,6R,7E,13R,16S,17S,21R,22R)-17-({4-O-[3-O-(3-Chloro-6-methoxy-2-methylbenzoyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]-2,6-dideoxy-β-D-arabino-hexopyranosyl}oxy)-28-hydroxy-3,22-dimethyl-23 ,26-dioxo-24,27-dioxapentacyclo[23.2.1.0.0.0]octacosa-4,7,14,25(28)-tetraene-4-carboxylic acid; Diuril; chlorothricin; Chlorosal; Chlortiazid; Clotride; 6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide,1,1-dioxide; Chlorurit

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 1050.8±65.0 °C at 760 mmHg
• 分子式: C₅₀H₆₃ClO₁₆
• 分子量: 955.479
• 闪点: 589.3±34.3 °C
• 精确质量: 954.380493
• PSA: 223.04000
• LogP: 9.13
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.619

生物活性

• 描述: 氯菊酯是一种抗生素,是猪心苹果酸脱氢酶的抑制剂[1]。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. P W Schindler, et al. Chlorothricin, and inhibitor of porcine-heart malate dehydrogenases, discriminating between the mitochondrial and cytoplasmic isoenzyme. Eur J Biochem. 1975 Feb 21;51(2):579-85.

合成路线

213122-67-9 ~89% 34707-92-1

文献：Roush, William R.; Sciotti, Richard J. Journal of the American Chemical Society, 1998 , vol. 120, # 30 p. 7411 - 7419

213122-74-8 ~% 34707-92-1

文献：Roush, William R.; Sciotti, Richard J. Journal of the American Chemical Society, 1994 , vol. 116, # 14 p. 6457 - 6458

157944-74-6 ~% 34707-92-1

文献：Roush, William R.; Sciotti, Richard J. Journal of the American Chemical Society, 1994 , vol. 116, # 14 p. 6457 - 6458

157944-73-5 ~% 34707-92-1

文献：Roush, William R.; Sciotti, Richard J. Journal of the American Chemical Society, 1994 , vol. 116, # 14 p. 6457 - 6458

157944-72-4 ~% 34707-92-1

文献：Roush, William R.; Sciotti, Richard J. Journal of the American Chemical Society, 1994 , vol. 116, # 14 p. 6457 - 6458

213122-73-7 ~% 34707-92-1

文献：Roush, William R.; Sciotti, Richard J. Journal of the American Chemical Society, 1998 , vol. 120, # 30 p. 7411 - 7419

157944-69-9 ~% 34707-92-1

文献：Roush, William R.; Sciotti, Richard J. Journal of the American Chemical Society, 1998 , vol. 120, # 30 p. 7411 - 7419

157944-71-3 ~% 34707-92-1

文献：Roush, William R.; Sciotti, Richard J. Journal of the American Chemical Society, 1998 , vol. 120, # 30 p. 7411 - 7419

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