59227-89-3

• 常用中文名：月桂氮酮
• 常用英文名：Laurocapram
• CAS号：59227-89-3
• 分子式：C₁₈H₃₅NO
• 分子量：281.477
• 相关类别： 研究领域 其他
• 发布时间：2018-04-06 08:00:00
• 更新时间：2024-01-01 22:48:07
• Laurocapram 是一种吸收促进剂,对于亲脂性和亲水性物质都是最有效的吸收剂之一。

名称

• 中文名: 氮酮
• 英文名: Laurocapram
• 中文别名: 月桂氮卓酮; 月桂氮酮
• 英文别名: 1-dodecyl-hexahydro-azepin-2-one; MFCD00190580; 2H-Azepin-2-one, 1-dodecylhexahydro-; tranzone; acecloguanosine; EINECS 261-668-9; 1-Dodecylazepan-2-one; Lauocapram; 1 dodecylperhydroazepin 2 one; AZONE; N-Dodecyl-e-caprolactam; azon; 1-Dodecyl-2-azepanone; 1-dodecylhexahydro-2H-azepin-2-one; usafnd-72; Laurocapram; 1-N-dodecylazacycloheptan-2-one

物化性质

• 密度: 0.9±0.1 g/cm3
• 沸点: 404.9±14.0 °C at 760 mmHg
• 熔点: -7ºC
• 分子式: C₁₈H₃₅NO
• 分子量: 281.477
• 闪点: 165.2±10.7 °C
• 精确质量: 281.271851
• PSA: 20.31000
• LogP: 6.57
• 外观性状: 无色或淡黄色透明液体
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.466
• 储存条件: 室温
• 水溶解性: 水溶性：不溶；水溶解度：0.171 mg/l 25 °C

生物活性

• 描述: Laurocapram 是一种吸收促进剂,对于亲脂性和亲水性物质都是最有效的吸收剂之一。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. López-Cervantes M, et al. Chemical enhancers for the absorption of substances through the skin: Laurocapram and its derivatives. Drug Dev Ind Pharm. 2006 Mar;32(3):267-86.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Laurocapram Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Laurocapram CAS number:59227-89-3 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C18H35NO Molecular weight:281.5 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CM3995000 CHEMICAL NAME : 2H-Azepin-2-one, hexahydro-N-lauryl- CAS REGISTRY NUMBER : 59227-89-3 BEILSTEIN REFERENCE NO. : 0167211 LAST UPDATED : 199806 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C18-H35-N-O MOLECULAR WEIGHT : 281.54 WISWESSER LINE NOTATION : T7NVTJ A12 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960- Volume(issue)/page/year: 118,474,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933790090

合成路线

105-60-2 143-15-7 ~99% 59227-89-3

文献：KOEI Chemical Co., Ltd. Patent: US4812566 A1, 1989 ;

143-15-7 ~% 59227-89-3

文献：US4422970 A1, ;

112-52-7 ~93% 59227-89-3

文献：KOEI Chemical Co., Ltd. Patent: US4812566 A1, 1989 ;

105-60-2 1634-04-4 143-15-7 ~% 59227-89-3

文献：US5986092 A1, ;

112-53-8 ~% 59227-89-3

文献：JAOCS, Journal of the American Oil Chemists' Society, , vol. 73, # 7 p. 847 - 850

105-60-2 ~% 59227-89-3

文献：Journal of Organic Chemistry, , vol. 18, p. 1087,1088

上下游产品

上游产品  5
105-60-2 143-15-7 112-52-7 1634-04-4
112-53-8
下游产品  0

海关

海关编码	2933790090
中文概述	2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:9.0% 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%