Laurocapram

Modify Date: 2024-01-01 22:48:07

Laurocapram structure	Common Name	Laurocapram
	CAS Number	59227-89-3	Molecular Weight	281.477
	Density	0.9±0.1 g/cm3	Boiling Point	404.9±14.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₃₅NO	Melting Point	-7ºC
	MSDS	USA	Flash Point	165.2±10.7 °C

Use of Laurocapram

Laurocapram is a absorption enhancer and has been one of the most effective for substances of both lipophilic and hydrophilic nature[1].

Name	Laurocapram
Synonym	More Synonyms

Description	Laurocapram is a absorption enhancer and has been one of the most effective for substances of both lipophilic and hydrophilic nature[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. López-Cervantes M, et al. Chemical enhancers for the absorption of substances through the skin: Laurocapram and its derivatives. Drug Dev Ind Pharm. 2006 Mar;32(3):267-86.

Density	0.9±0.1 g/cm3
Boiling Point	404.9±14.0 °C at 760 mmHg
Melting Point	-7ºC
Molecular Formula	C₁₈H₃₅NO
Molecular Weight	281.477
Flash Point	165.2±10.7 °C
Exact Mass	281.271851
PSA	20.31000
LogP	6.57
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.466

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: Laurocapram
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:Laurocapram
CAS number:59227-89-3

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C18H35NO
Molecular weight:281.5

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CM3995000

CHEMICAL NAME :: 2H-Azepin-2-one, hexahydro-N-lauryl-

CAS REGISTRY NUMBER :: 59227-89-3

BEILSTEIN REFERENCE NO. :: 0167211

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C18-H35-N-O

MOLECULAR WEIGHT :: 281.54

WISWESSER LINE NOTATION :: T7NVTJ A12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960- Volume(issue)/page/year: 118,474,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

Hazard Codes	Xi
HS Code	2933790090

Caprolactam

CAS#:105-60-2

1-Bromododecane

CAS#:143-15-7

~99%

Laurocapram

CAS#:59227-89-3

Literature: KOEI Chemical Co., Ltd. Patent: US4812566 A1, 1989 ;

1-Bromododecane

CAS#:143-15-7

Laurocapram

CAS#:59227-89-3

Literature: US4422970 A1, ;

1-Chlorododecane

CAS#:112-52-7

~93%

Laurocapram

CAS#:59227-89-3

Literature: KOEI Chemical Co., Ltd. Patent: US4812566 A1, 1989 ;

Caprolactam

CAS#:105-60-2

Methyl tert-but...

CAS#:1634-04-4

1-Bromododecane

CAS#:143-15-7

Laurocapram

CAS#:59227-89-3

Literature: US5986092 A1, ;

1-Dodecanol

CAS#:112-53-8

Laurocapram

CAS#:59227-89-3

Literature: JAOCS, Journal of the American Oil Chemists' Society, , vol. 73, # 7 p. 847 - 850

Caprolactam

CAS#:105-60-2

Laurocapram

CAS#:59227-89-3

Literature: Journal of Organic Chemistry, , vol. 18, p. 1087,1088

Precursor 5
CAS#:105-60-2 Caprolactam CAS#:143-15-7 1-Bromododecane CAS#:112-52-7 1-Chlorododecane CAS#:1634-04-4 Methyl tert-but...
CAS#:112-53-8 1-Dodecanol
DownStream 0

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

1-dodecyl-hexahydro-azepin-2-one

MFCD00190580

2H-Azepin-2-one, 1-dodecylhexahydro-

tranzone

acecloguanosine

EINECS 261-668-9

1-Dodecylazepan-2-one

Lauocapram

1 dodecylperhydroazepin 2 one

AZONE

N-Dodecyl-e-caprolactam

azon

1-Dodecyl-2-azepanone

1-dodecylhexahydro-2H-azepin-2-one

usafnd-72

Laurocapram

1-N-dodecylazacycloheptan-2-one

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Laurocapram
Price: ￥Inquiry/1mg ￥78.0/100ml ￥298.0/500ml
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Laurocapram
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Laurocapram
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Laurocapram
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥85/100g

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Laurocapram

Use of Laurocapram

Names

Laurocapram Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

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