上海化源生化科技有限公司
上海市上海市普陀区
产品名：二氯苯二磺胺
纯度：98.0%
规格：
联系人：徐经理
联系电话：133 1186 9306

上海源溪生物科技有限公司
上海市上海市浦东新区
产品名：Dichlorphenamide (Diclofenamide)
纯度：98.9%
规格：1g
联系人：赖经理
联系电话：13564518121

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Dichlorphenamide
纯度：98.0%
规格：100mg/1g/50mg/50mg
联系人：李先生
联系电话：18916172912

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：双氯非那胺
纯度：95.0%
规格：1g/250mg/50mg/1g
联系人：阿拉丁
联系电话：400-620-6333

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120-97-8生产厂家

120-97-8价格

120-97-8

120-97-8结构式

常用中文名：双氯非那胺
常用英文名：diclofenamide
CAS号：120-97-8
分子式：C₆H₆Cl₂N₂O₄S₂
分子量：305.159
相关类别：原料药泌尿系统用药利尿药
发布时间：2018-07-13 06:17:13
更新时间：2025-08-21 11:11:42
Dichlorphenamide(Diclofenamide)是碳酸酐酶抑制剂。

化源商城直购

中文名	双氯非那胺
英文名	diclofenamide
中文别名	4,5-二氯苯-1,3-二磺酰胺二氯苯二磺胺
英文别名	Dichlorophenamide diclofenamide diclofenamidum [INN_la] MFCD00148948 1,3-Benzenedisulfonamide, 4,5-dichloro- 4,5-Dichlorobenzene-1,3-Disulfonamide 4,5-Dichloro-1,3-benzenedisulfonamide EINECS 204-440-6 Dichlorphenamide

描述	Dichlorphenamide(Diclofenamide)是碳酸酐酶抑制剂。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶研究领域 >> 神经疾病
参考文献	[1]. Kanski, J.J., Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors. Br J Ophthalmol, 1968. 52(8): p. 642-3. [2]. Rucquoy, M. and L. Sorel, Diclofenamide in the treatment of therapy-resistant epilepsy. Acta Neurol Belg, 1978. 78(3): p. 174-82.

密度	1.8±0.1 g/cm3
沸点	590.5±60.0 °C at 760 mmHg
熔点	239-241ºC
分子式	C₆H₆Cl₂N₂O₄S₂
分子量	305.159
闪点	310.9±32.9 °C
精确质量	303.914612
PSA	137.08000
LogP	0.93
外观性状	白色或几乎白色结晶粉末
蒸汽压	0.0±1.7 mmHg at 25°C
折射率	1.635
储存条件	存放于惰性气体之中;避免空气
稳定性	一、基本性质白色或近白色结晶性粉末。熔点239-241℃。溶于乙醇，易溶于碱性溶液，几乎不溶于水或氯仿。无臭，味微苦。
水溶解性	水溶性：不溶
分子结构	五、分子性质数据： 1、摩尔折射率：61.28 2、摩尔体积（m³/mol）：171.2 3、等张比容（90.2K）：494.9 4、表面张力（dyne/cm）：69.7 5、介电常数： 6、偶极距（10 ^-24cm ³）： 7、极化率：24.29
计算化学	1.疏水参数计算参考值（XlogP）:0.3 2.氢键供体数量:2 3.氢键受体数量:6 4.可旋转化学键数量:2 5.互变异构体数量:无 6.拓扑分子极性表面积137 7.重原子数量:16 8.表面电荷:0 9.复杂度:452 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：白色或近白色结晶性粉末 2. 熔点（℃）：239~241

毒理学数据:

1、急性毒性数据：大鼠经口LD50：10070mg/kg

大鼠腹膜腔LD50：1244mg/kg

小鼠经口LD50：1710mg/kg

小鼠腹膜腔LD50：304mg/kg

小鼠静脉注射LD50：643mg/kg

狗静脉注射LD50：200mg/kg

2、生殖毒性数据：大鼠（雌）经口TDLO：4642mg/kg/1-22D

小鼠（雌）经腹膜腔TDLO：500mg/kg/10D

小鼠（雌）经皮下TDLO：96mg/kg/15D

小鼠（雌）经肠胃TDLO：144mg/kg/13D

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ9200000

CHEMICAL NAME :: m-Benzenedisulfonamide, 4,5-dichloro-

CAS REGISTRY NUMBER :: 120-97-8

BEILSTEIN REFERENCE NO. :: 2703329

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C6-H6-Cl2-N2-O4-S2

MOLECULAR WEIGHT :: 305.16

WISWESSER LINE NOTATION :: ZSWR BG CG ESZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,446,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1244 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,446,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 304 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 19,1423,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 643 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4642 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 126,6,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 500 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 11,31,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 96 mg/kg

SEX/DURATION :: female 15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :: DEBIAO Developmental Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,395,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 144 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,239,1971

危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R63
安全声明 (欧洲)	S36
危险品运输编码	NONH for all modes of transport
RTECS号	CZ9200000
海关编码	2935009090

70269-54-4

120-97-8

文献：US2835702 , ;

上游产品 1
70269-54-4
下游产品 0

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

120-97-8	671-95-4
121-30-2	473-34-7
80-13-7	139920-32-4
145701-21-9	78213-16-8
58727-01-8	119623-66-4
2171711-90-1	2227891-14-5
937194-99-5	6723-95-1
2137783-18-5	2171360-44-2
2227794-11-6	2171284-43-6
2171151-05-4	2171444-61-2

120-97-8

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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