99464-64-9

• 常用中文名：安吡昔康
• 常用英文名：ampiroxicam
• CAS号：99464-64-9
• 分子式：C₂₀H₂₁N₃O₇S
• 分子量：447.462
• 相关类别： 原料药 解热镇痛药 非甾抗炎药
• 发布时间：2018-08-13 18:27:23
• 更新时间：2026-07-08 20:47:31
• Ampiroxicam(CP65703)是非选择性的环氧化酶抑制剂,有抗炎活性。

名称

• 中文名: 安吡昔康
• 英文名: ampiroxicam
• 中文别名: 安吡昔康,10 MM DMSO 溶液; 安吡昔康(安碧罗康); 4-[1-(乙氧羰基氧)-乙氧基]-2-甲基-N-(2-吡啶基)-2H-苯并噻嗪-3-甲酰胺-1,1; (1-((2-甲基-1,1-二氧代-3-(吡啶-2-基氨甲酰基)-2H-苯并[E][1,2]噻嗪-4-基)氧基)乙基)碳酸乙酯; 氨吡昔康; 4-[1-(乙氧羰基氧)-乙氧基]-2-甲基-N-(2-吡啶基)-2H-苯并噻嗪-3-甲酰胺-1,1-二氧化物; 安碧罗康; 索非那新琥珀酸盐
• 英文别名: (±)-4-(1-Hydroxyethoxy)-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide ethyl carbonate (ester) 1,1-dioxide; 4-[1-(ethoxycbonyloxy)ethoxy]-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazine-3-cboxamide-1,1-dioxide; AMPICILLINTRIHYDRATOWDER; 4-{1-[(Ethoxycarbonyl)oxy]ethoxy}-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide S,S-dioxide; 65703;FLUCAM;NASIL;65703;-65703; 4-[1-(Ethoxycbonyloxy)ethoxy]-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-cboxamide 1,1-Dioxide; iazin-4-yl)oxy)ethylester,s,s-dioxide; AmpiroxicamQ: What is Ampiroxicam Q: What is the CAS Number of Ampiroxicam Q: What is the storage condition of Ampiroxicam Q: What e the applications of Ampiroxicam; 4-(1-Acetyloxyethoxy)-3-[[(2-pyridinyl)amino]carbonyl]-2-methyl-2H-1,2-benzothiazine 1,1-dioxide; Ampiroxicamum [Latin]; 4-[1-(Ethoxycarbonyloxy)ethoxy]-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide; Nasil; Carbonic acid, ethyl 1-[[2-methyl-1,1-dioxido-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester; ethyl 1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1λ⁶,2-benzothiazin-4-yl]oxy]ethyl carbonate; 3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-cboxylic acid methyl ester; Cbonic acid, ethyl 1-[[2-methyl-1,1-dioxido-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester; Ampiroam; Ampiroxicam; Ampiroxicam, 10 mM in DMSO; ETHYL 1-([2-METHYL-1,1-DIOXIDO-3-[(2-PYRIDINYLAMINO)carbonyl]-2H-1,2-BENZOTHIAZIN-4-YL]OXY)ETHYL CBONATE; Ethyl 1-{[2-methyl-1,1-dioxido-3-(pyridin-2-ylcarbamoyl)-2H-1,2-benzothiazin-4-yl]oxy}ethyl carbonate; cbonicacid,ethyl1-((2-methyl-3-((2-pyridinylamino)carbonyl)-2h-1,2-benzoth; Ethyl 1-{[2-methyl-1,1-dioxido-3-(2-pyridinylcarbamoyl)-2H-1,2-benzothiazin-4-yl]oxy}ethyl carbonate; 4-[1-(Ethoxycarbonyloxy)ethoxy]-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide; MFCD00866079; Cbonic acid, ethyl 1-[[2-methyl-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester, S,S-dioxide; 99-9 Ampiroxicam; Ampiroxicam //BP; Flucam; 2H-1,2-Benzothiazine, cbonic acid deriv; ethyl 1-{[2-methyl-1,1-dioxido-3-(pyridin-2-ylcbamoyl)-2h-1,2-benzothiazin-4-yl]oxy}ethyl cbonate; Ethyl (1-((2-methyl-1,1-dioxido-3-(pyridin-2-ylcbamoyl)-2H-benzo[e][1,2]thiazin-4-yl)oxy)ethyl) cbonate; Ampiroxicam - Bio-X; Ampiroxicamum

物化性质

• 密度: 1.4±0.1 g/cm3
• 熔点: 159-161?C
• 分子式: C₂₀H₂₁N₃O₇S
• 分子量: 447.462
• 精确质量: 447.110016
• PSA: 132.51000
• LogP: 3.12
• 折射率: 1.630
• 储存条件: -20°C Freezer

生物活性

• 描述: Ampiroxicam(CP65703)是非选择性的环氧化酶抑制剂,有抗炎活性。
• 相关类别:
  天然产物 >> 生物碱
  研究领域 >> 炎症/免疫
• 靶点:

  COX

• 参考文献:

  [1]. Aoki T, et al. Premedication with cyclooxygenase-2 inhibitor meloxicam reduced postoperative pain in patients after oral surgery. Int J Oral Maxillofac Surg. 2006 Jul;35(7):613-7.

  [2]. Sasaki, T., et al., Antigenic characterization in ampiroxicam-induced photosensitivity using an in vivo model of contact hypersensitivity. J Dermatol Sci, 1999. 21(3): p. 170-5.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport
• RTECS号: FG1602400
• 海关编码: 2942000000

合成路线

50893-36-2 36322-90-4 ~% 99464-64-9

文献：US4551452 A1, ;

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海关

海关编码	2942000000