26844-12-2

• 常用中文名：吲哌胺
• 常用英文名：Indoramin
• CAS号：26844-12-2
• 分子式：C₂₂H₂₅N₃O
• 分子量：347.45300
• 相关类别： 原料药 循环系统用药 抗高血压病药
• 发布时间：2018-06-26 17:18:06
• 更新时间：2024-01-04 09:59:21
• 吲哚美辛是一种口服活性抗高血压药物。吲哚美辛对α1A肾上腺素受体也有选择性[1]。

名称

• 中文名: 吲哚拉明
• 英文名: N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide
• 中文别名: 3-[2-(4-苯酰胺-1-哌啶)乙基]吲哚; 吲哌胺
• 英文别名: 3-<2-(4-Benzamidopiperid-1-yl)ethyl>indol; Indoramine [INN-French]; N-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-benzamide; 3-[2-(4-benzamido-1-piperidyl)ethyl]indole; INDORAMIN; Indoramine; 3-[2-(4-benzamidopiperid-1-yl)ethyl]indole; Indoramina [INN-Spanish]; EINECS 248-041-5; Benzamide,N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl); Indoraminum [INN-Latin]

物化性质

• 密度: 1.21g/cm3
• 沸点: 600ºC at 760mmHg
• 熔点: 208-210°
• 分子式: C₂₂H₂₅N₃O
• 分子量: 347.45300
• 闪点: 316.7ºC
• 精确质量: 347.20000
• PSA: 48.13000
• LogP: 3.93360
• 蒸汽压: 2.36E-14mmHg at 25°C
• 折射率: 1.657

生物活性

• 描述: 吲哚美辛是一种口服活性抗高血压药物。吲哚美辛对α1A肾上腺素受体也有选择性[1]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
• 参考文献:

  [1]. M Eltze, et al. In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CV5395900 CHEMICAL NAME : Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)- CAS REGISTRY NUMBER : 26844-12-2 BEILSTEIN REFERENCE NO. : 0494035 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C22-H25-N3-O MOLECULAR WEIGHT : 347.50 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >400 mg/kg TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971

安全

• 海关编码: 2933990090

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%