2141-09-5

• 常用中文名：木兰花碱
• 常用英文名：Magnoflorine
• CAS号：2141-09-5
• 分子式：C₂₀H₂₄NO₄+
• 分子量：342.408
• 相关类别： 天然产物 生物碱
• 发布时间：2018-09-18 20:10:48
• 更新时间：2025-08-23 17:12:23
• (+)-Magnoflorine (Magnoflorine) 是从 Acoruscalamus 中分到的阿朴啡生物碱,具有抗真菌活性,减少 C. albicans 生物膜的形成。具有抗氧化、抗糖尿病的作用。

名称

• 中文名: 碘化木兰花碱
• 英文名: (+)-magnoflorine iodide
• 中文别名: 木兰花碱; 唐松草碱; 玉兰碱
• 英文别名: 4H-Dibenzo[de,g]quinolinium, 5,6,6a,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-, (6aS)-; Magflorine; escholin; Magnoflorine; Aporphine alkaloid; escholine; (6aS)-1,11-Dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium; Thalictrine; UNII-NI8K6962K4; THALICTRIN; (S)-5,6,6a,7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium; Esholine

物化性质

• 熔点: 252ºC
• 分子式: C₂₀H₂₄NO₄+
• 分子量: 342.408
• 精确质量: 342.169983
• PSA: 58.92000
• LogP: -1.71
• 储存条件: 2-8C

生物活性

• 描述: (+)-Magnoflorine (Magnoflorine) 是从 Acoruscalamus 中分到的阿朴啡生物碱,具有抗真菌活性,减少 C. albicans 生物膜的形成。具有抗氧化、抗糖尿病的作用。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
  研究领域 >> 代谢疾病
• 靶点:

  Fungal[1]

• 参考文献:

  [1]. Kim J, et al. Antifungal activity of magnoflorine against Candida strains. World J Microbiol Biotechnol. 2018 Oct 31;34(11):167.

  [2]. Haque MA, et al. Magnoflorine Enhances LPS-Activated Pro-Inflammatory Responses via MyD88-Dependent Pathways in U937 Macrophages. Planta Med. 2018 Nov;84(17):1255-1264.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HQ1777600 CHEMICAL NAME : 4H-Dibenzo(de,g)quinolinium, 5,6,6a,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6 -dimethyl-, (S)- CAS REGISTRY NUMBER : 2141-09-5 LAST UPDATED : 199503 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C20-H24-N-O4 MOLECULAR WEIGHT : 342.45 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 19600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 138 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302 + H312 + H332
• 警示性声明: P261-P280-P301 + P312 + P330-P302 + P352 + P312-P304 + P340 + P312
• 危险品运输编码: NONH for all modes of transport
• RTECS号: HQ1777600