380378-81-4

• 常用中文名：BILR 355
• 常用英文名：BILR 355
• CAS号：380378-81-4
• 分子式：C₂₅H₂₃N₅O₃
• 分子量：441.48200
• 相关类别： 信号通路 抗感染 HIV
• 发布时间：2017-10-01 15:24:39
• 更新时间：2025-08-25 10:13:14
• BILR 355 是第二代非核苷逆转录酶 (reverse transcriptase) 抑制剂 (NNRTI)。BILR 355 对 HIV-1 逆转录酶 (RT) 具有高度特异性。BILR 355 可用于 HIV 感染研究。

名称

• 英文名: 11-ethyl-5-methyl-8-[2-(1-oxidoquinolin-1-ium-4-yl)oxyethyl]dipyrido[2,3-d:2',3'-h][1,4]diazepin-6-one
• 英文别名: 5-ethyl-10-methyl-2-[2-(1-oxyquinolin-4-yloxy)ethyl]-5,10-dihydro-4,5,6,10-tetraazadibenzo[a,d]cyclohepten-11-one; BILR 355 BS; 6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one,11-ethyl-5,11-dihydro-5-methyl-8-[2-[(1-oxido-4-quinolinyl)oxy]ethyl]; DIP007; 6H-Dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one,11-ethyl-5,11-dihydro-5-methyl-8-[2-[(1-oxido-4-quinolinyl)oxy]ethyl]; 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one HCl; 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2',3'-e]10 [1,4]diazepin-6-one HCl; 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

物化性质

• 分子式: C₂₅H₂₃N₅O₃
• 分子量: 441.48200
• 精确质量: 441.18000
• PSA: 87.40000
• LogP: 4.06850

生物活性

• 描述: BILR 355 是第二代非核苷逆转录酶 (reverse transcriptase) 抑制剂 (NNRTI)。BILR 355 对 HIV-1 逆转录酶 (RT) 具有高度特异性。BILR 355 可用于 HIV 感染研究。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 逆转录酶
• 参考文献:

  [1]. Fenglei Huang, et al. Pharmacokinetic and safety evaluation of BILR 355, a second-generation nonnucleoside reverse transcriptase inhibitor, in healthy volunteers. Antimicrob Agents Chemother. 2008 Dec;52(12):4300-7.

合成路线

380378-84-7 ~74% 380378-81-4

文献：Simoneau, Bruno Patent: US2002/28807 A1, 2002 ;

886468-35-5 ~85% 380378-81-4

文献：Busacca, Carl A.; Cerreta, Mike; Dong, Yong; Eriksson, Magnus C.; Farina, Vittorio; Feng, XuWu; Kim, Ji-Young; Lorenz, Jon C.; Sarvestani, Max; Simpson, Robert; Varsolona, Rieh; Vitous, Jana; Campbell, Scot J.; Davis, Mark S.; Jones, Paul-James; Norwood, Daniel; Qiu, Fenghe; Beaulieu, Pierre L.; Duceppe, Jean-Simon; Hache, Bruno; Brong, Jim; Chiu, Fang-Ting; Curtis, Tom; Kelley, Jason; Lo, Young S.; Powner, Tory H. Organic Process Research and Development, 2008 , vol. 12, # 4 p. 603 - 613

609-71-2 ~% 380378-81-4

文献：Busacca, Carl A.; Cerreta, Mike; Dong, Yong; Eriksson, Magnus C.; Farina, Vittorio; Feng, XuWu; Kim, Ji-Young; Lorenz, Jon C.; Sarvestani, Max; Simpson, Robert; Varsolona, Rieh; Vitous, Jana; Campbell, Scot J.; Davis, Mark S.; Jones, Paul-James; Norwood, Daniel; Qiu, Fenghe; Beaulieu, Pierre L.; Duceppe, Jean-Simon; Hache, Bruno; Brong, Jim; Chiu, Fang-Ting; Curtis, Tom; Kelley, Jason; Lo, Young S.; Powner, Tory H. Organic Process Research and Development, 2008 , vol. 12, # 4 p. 603 - 613

104612-36-4 ~% 380378-81-4

文献：Busacca, Carl A.; Cerreta, Mike; Dong, Yong; Eriksson, Magnus C.; Farina, Vittorio; Feng, XuWu; Kim, Ji-Young; Lorenz, Jon C.; Sarvestani, Max; Simpson, Robert; Varsolona, Rieh; Vitous, Jana; Campbell, Scot J.; Davis, Mark S.; Jones, Paul-James; Norwood, Daniel; Qiu, Fenghe; Beaulieu, Pierre L.; Duceppe, Jean-Simon; Hache, Bruno; Brong, Jim; Chiu, Fang-Ting; Curtis, Tom; Kelley, Jason; Lo, Young S.; Powner, Tory H. Organic Process Research and Development, 2008 , vol. 12, # 4 p. 603 - 613

134698-42-3 ~% 380378-81-4

文献：Busacca, Carl A.; Cerreta, Mike; Dong, Yong; Eriksson, Magnus C.; Farina, Vittorio; Feng, XuWu; Kim, Ji-Young; Lorenz, Jon C.; Sarvestani, Max; Simpson, Robert; Varsolona, Rieh; Vitous, Jana; Campbell, Scot J.; Davis, Mark S.; Jones, Paul-James; Norwood, Daniel; Qiu, Fenghe; Beaulieu, Pierre L.; Duceppe, Jean-Simon; Hache, Bruno; Brong, Jim; Chiu, Fang-Ting; Curtis, Tom; Kelley, Jason; Lo, Young S.; Powner, Tory H. Organic Process Research and Development, 2008 , vol. 12, # 4 p. 603 - 613

78686-86-9 ~% 380378-81-4

文献：Busacca, Carl A.; Cerreta, Mike; Dong, Yong; Eriksson, Magnus C.; Farina, Vittorio; Feng, XuWu; Kim, Ji-Young; Lorenz, Jon C.; Sarvestani, Max; Simpson, Robert; Varsolona, Rieh; Vitous, Jana; Campbell, Scot J.; Davis, Mark S.; Jones, Paul-James; Norwood, Daniel; Qiu, Fenghe; Beaulieu, Pierre L.; Duceppe, Jean-Simon; Hache, Bruno; Brong, Jim; Chiu, Fang-Ting; Curtis, Tom; Kelley, Jason; Lo, Young S.; Powner, Tory H. Organic Process Research and Development, 2008 , vol. 12, # 4 p. 603 - 613

162109-00-4 ~% 380378-81-4

文献：Busacca, Carl A.; Cerreta, Mike; Dong, Yong; Eriksson, Magnus C.; Farina, Vittorio; Feng, XuWu; Kim, Ji-Young; Lorenz, Jon C.; Sarvestani, Max; Simpson, Robert; Varsolona, Rieh; Vitous, Jana; Campbell, Scot J.; Davis, Mark S.; Jones, Paul-James; Norwood, Daniel; Qiu, Fenghe; Beaulieu, Pierre L.; Duceppe, Jean-Simon; Hache, Bruno; Brong, Jim; Chiu, Fang-Ting; Curtis, Tom; Kelley, Jason; Lo, Young S.; Powner, Tory H. Organic Process Research and Development, 2008 , vol. 12, # 4 p. 603 - 613

639469-44-6 ~% 380378-81-4

文献：Busacca, Carl A.; Cerreta, Mike; Dong, Yong; Eriksson, Magnus C.; Farina, Vittorio; Feng, XuWu; Kim, Ji-Young; Lorenz, Jon C.; Sarvestani, Max; Simpson, Robert; Varsolona, Rieh; Vitous, Jana; Campbell, Scot J.; Davis, Mark S.; Jones, Paul-James; Norwood, Daniel; Qiu, Fenghe; Beaulieu, Pierre L.; Duceppe, Jean-Simon; Hache, Bruno; Brong, Jim; Chiu, Fang-Ting; Curtis, Tom; Kelley, Jason; Lo, Young S.; Powner, Tory H. Organic Process Research and Development, 2008 , vol. 12, # 4 p. 603 - 613

611-36-9 ~% 380378-81-4

文献：Busacca, Carl A.; Cerreta, Mike; Dong, Yong; Eriksson, Magnus C.; Farina, Vittorio; Feng, XuWu; Kim, Ji-Young; Lorenz, Jon C.; Sarvestani, Max; Simpson, Robert; Varsolona, Rieh; Vitous, Jana; Campbell, Scot J.; Davis, Mark S.; Jones, Paul-James; Norwood, Daniel; Qiu, Fenghe; Beaulieu, Pierre L.; Duceppe, Jean-Simon; Hache, Bruno; Brong, Jim; Chiu, Fang-Ting; Curtis, Tom; Kelley, Jason; Lo, Young S.; Powner, Tory H. Organic Process Research and Development, 2008 , vol. 12, # 4 p. 603 - 613

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380378-84-7 609-71-2 104612-36-4 134698-42-3
78686-86-9 162109-00-4 639469-44-6 611-36-9
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