26116-56-3

• 常用中文名：9(S)-红霉素胺
• 常用英文名：9(S)-Erythromycylamine
• CAS号：26116-56-3
• 分子式：C₃₇H₇₀N₂O₁₂
• 分子量：734.96
• 相关类别： 研究领域 感染
• 发布时间：2018-12-03 12:50:48
• 更新时间：2024-01-02 08:59:22
• Erythromycylamine 是一种大环内酯类抗生素。Erythromycylamine 对大多数革兰氏阳性球菌和结核分枝杆菌具有抗菌活性。

名称

• 中文名: (9S)-9-氨基-9-脱氧乙琥红霉素
• 英文名: Erythromycylamine
• 英文别名: MFCD00872156

物化性质

• 密度: 1.19g/cm3
• 沸点: 810.3ºC at 760mmHg
• 分子式: C₃₇H₇₀N₂O₁₂
• 分子量: 734.96
• 闪点: 443.8ºC
• 精确质量: 734.49300
• PSA: 202.86000
• LogP: 2.24410
• 蒸汽压: 2.15E-30mmHg at 25°C
• 折射率: 1.539
• 储存条件: 2-8°C

生物活性

• 描述: Erythromycylamine 是一种大环内酯类抗生素。Erythromycylamine 对大多数革兰氏阳性球菌和结核分枝杆菌具有抗菌活性。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Naik S, et al. In vitro activities of several new macrolide antibiotics against Mycobacterium avium complex. Antimicrob Agents Chemother. 1989 Sep;33(9):1614-6.

  [2]. Fernandes CJ, et al. Multi-centre collaborative study for the in vitro evaluation of new macrolides dirithromycin and erythromycylamine. Australian Group for Antimicrobial Resistance (AGAR). Pathology. 1995 Jan;27(1):74-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KF4590000 CHEMICAL NAME : Erythromycin, 9-amino-9-deoxo-, stereoisomer CAS REGISTRY NUMBER : 26116-56-3 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C37-H70-N2-O12 MOLECULAR WEIGHT : 735.09 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 57500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978

安全

• 危害码 (欧洲): Xi,N
• 风险声明 (欧洲): 41-50/53
• 安全声明 (欧洲): 26-39-60-61

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