387-79-1

• 常用中文名：17α-羟孕烯醇酮
• 常用英文名：17a-Hydroxypregnenolone
• CAS号：387-79-1
• 分子式：C₂₁H₃₂O₃
• 分子量：334.493
• 相关类别： 研究领域 内分泌
• 发布时间：2018-09-26 15:25:00
• 更新时间：2024-01-02 07:25:15
• 17a-Hydroxypregnenolone 是一种孕烷类固醇, 是形成脱氢表雄酮 (DHEA) 的一种激素原。

名称

• 中文名: 17Alpha-羟基妊娠烯醇酮
• 英文名: 17α-hydroxypregnenolone
• 中文别名: 17-羟基孕尿烯酮; 3Β,17Α-二羟基-5-孕烯-20酮; 17a-羟基孕烯醇酮
• 英文别名: MFCD00021129; Pregnan-2-one, 3,17-dihydroxy-; Hydroxypregnenolone; EINECS 206-862-6; HYDROXYPREGNENOLONE,17A; 17a-Hydroxypregnolone; 17alpha-Hydroxy; 5-Pregnen-3.β.,17.α.-diol-20-one; 17-OH PREG; 3,17-Dihydroxypregnan-2-one; 17-OH-pregnenolone; 17A-HYDROXY PREGNENOLONE; 17alpha-hydroxypregnenolone; 17-Hydroxy Pregnenolone; 17A-HYDROXYPREGENOLONE

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 468.1±40.0 °C at 760 mmHg
• 熔点: 273℃
• 分子式: C₂₁H₃₂O₃
• 分子量: 334.493
• 闪点: 251.0±23.8 °C
• 精确质量: 334.250793
• PSA: 57.53000
• LogP: 3.46
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.540
• 储存条件: ?20°C

生物活性

• 描述: 17a-Hydroxypregnenolone 是一种孕烷类固醇, 是形成脱氢表雄酮 (DHEA) 的一种激素原。
• 相关类别:
  研究领域 >> 内分泌
• 靶点:

  Human Endogenous Metabolite

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU5548000 CHEMICAL NAME : Pregn-5-en-20-one, 3-beta,17-dihydroxy- CAS REGISTRY NUMBER : 387-79-1 LAST UPDATED : 198910 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C21-H32-O3 MOLECULAR WEIGHT : 332.53 WISWESSER LINE NOTATION : L E5 B666 LUTJ A1 E1 FV1 FQ OQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 99600 ug/kg SEX/DURATION : male 48 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 5,45,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 96 mg/kg SEX/DURATION : male 48 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,484,1973

安全

• 符号: GHS02, GHS06, GHS08
• 信号词: Danger
• 危害声明: H225-H301 + H311 + H331-H370
• 警示性声明: P210-P260-P280-P301 + P310-P311
• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): F,T
• 风险声明 (欧洲): 11-23/24/25-39/23/24/25
• 安全声明 (欧洲): 7-16-36/37-45
• 危险品运输编码: UN1230 - class 3 - PG 2 - Methanol
• WGK德国: 3
• RTECS号: TU5548000

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