518-11-6

• 常用中文名：COLCHICEINE, N-DEACETYL-N-METHYL-
• 常用英文名：COLCHICEINE, N-DEACETYL-N-METHYL-
• CAS号：518-11-6
• 分子式：C₂₀H₂₃NO₅
• 分子量：357.40000
• 发布时间：2017-12-15 16:29:49
• 更新时间：2025-08-31 19:06:06

名称

• 英文名: (7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
• 英文别名: Demecolcein; (S)-10-hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one; demecolceine; (7s)-9-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-10(5h)-one; (S)-10-Hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-on; N-Desacetyl-N-methylcolchiceine

物化性质

• 密度: 1.27g/cm3
• 沸点: 626.4ºC at 760 mmHg
• 分子式: C₂₀H₂₃NO₅
• 分子量: 357.40000
• 闪点: 332.6ºC
• 精确质量: 357.15800
• PSA: 77.02000
• LogP: 3.04280
• 折射率: 1.608

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0600000 CHEMICAL NAME : Colchiceine, N-deacetyl-N-methyl- CAS REGISTRY NUMBER : 518-11-6 LAST UPDATED : 198712 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C20-H23-N-O5 MOLECULAR WEIGHT : 357.44 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

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