Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Demecolceine
Price: Check
Purity: 95.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: COLCHICEINE, N-DEACETYL-N-METHYL-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

518-11-6

518-11-6 structure

518-11-6 structure

Name: COLCHICEINE, N-DEACETYL-N-METHYL-
Chemical Name: (7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
CAS Number: 518-11-6
Molecular Formula: C₂₀H₂₃NO₅
Molecular Weight: 357.40000
Create Date: 2017-12-15 16:29:49
Modify Date: 2025-08-31 19:06:06

Name	(7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
Synonyms	Demecolcein (S)-10-hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one demecolceine (7s)-9-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-10(5h)-one (S)-10-Hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-on N-Desacetyl-N-methylcolchiceine

Density	1.27g/cm3
Boiling Point	626.4ºC at 760 mmHg
Molecular Formula	C₂₀H₂₃NO₅
Molecular Weight	357.40000
Flash Point	332.6ºC
Exact Mass	357.15800
PSA	77.02000
LogP	3.04280
Index of Refraction	1.608

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0600000

CHEMICAL NAME :: Colchiceine, N-deacetyl-N-methyl-

CAS REGISTRY NUMBER :: 518-11-6

LAST UPDATED :: 198712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H23-N-O5

MOLECULAR WEIGHT :: 357.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

Precursor 5
477-30-5 64-86-8 3476-50-4 477-27-0
3482-37-9
DownStream 2
4702-33-4 477-30-5

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