985-13-7

• 常用中文名：盐酸依沙维林
• 常用英文名：Isoquinoline,1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-, hydrochloride (1:1)
• CAS号：985-13-7
• 分子式：C₂₄H₃₀ClNO₄
• 分子量：431.95200
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-06-05 08:00:00
• 更新时间：2024-01-07 12:06:50
• 罂粟碱的衍生物盐酸伊沙韦林抑制心脏L型钙通道。盐酸乙威林是一种外周血管扩张剂和解痉药。盐酸乙威林可用于外周血管疾病的研究[1][2][3]。

名称

• 中文名: 盐酸依沙维林
• 英文名: ethaverine hydrochloride
• 英文别名: Isoquinoline,1-(3,4-diethoxybenzyl)-6,7-diethoxy-,hydrochloride; 6,7-Diethoxy-1-(3,4-diethoxybenzyl)isoquinoline hydrochloride; Consenil; Balborin; Isovex; Barbonin hydrochloride; Cebral; Ethaquin; Ethylpapaverin hydrochloride

物化性质

• 密度: 1.104g/cm3
• 沸点: 527.1ºC at 760 mmHg
• 熔点: 187ºC
• 分子式: C₂₄H₃₀ClNO₄
• 分子量: 431.95200
• 闪点: 185.9ºC
• 精确质量: 431.18600
• PSA: 49.81000
• LogP: 6.22240
• 外观性状: 固体
• 储存条件: -20°C， 密封， 干燥

生物活性

• 描述: 罂粟碱的衍生物盐酸伊沙韦林抑制心脏L型钙通道。盐酸乙威林是一种外周血管扩张剂和解痉药。盐酸乙威林可用于外周血管疾病的研究[1][2][3]。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  信号通路 >> 神经信号通路 >> 单胺氧化酶
• 体外研究: 盐酸乙威林(10μM,PC12细胞) 通过阻断 L型电压敏感 钙离子通道来减少儿茶酚胺分泌[2]。 盐酸乙威林(12小时)通过抑制 第12页细胞中的酪氨酸羟化酶 (第)活性来降低多巴胺含量,国际50为 1.4μM[3]盐酸乙威林抑制小鼠脑中的单胺氧化酶 (毛)(分离自小鼠全脑) 活性,国际50为 25.5μM[6]
• 体内研究: 将盐酸乙威林(2-10mg/kg静脉滴注,静脉注射)引起豚鼠耳蜗内电位显着升高[4]。 Ethaverine(1-10mg/kg静脉注射) 抑制麻醉狗的房室传导和心率[5]。 动物模型：狗[5]剂量：1和10 mg/kg给药：静脉注射结果：抑制房室传导和心率。
• 参考文献:

  [1]. Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40(5):750-5.

  [2]. Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47(7):1262-6.

  [3]. Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24(1):103-5.

  [4]. Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Arch Otolaryngol. 1981 Apr;107(4):227-9.

  [5]. Lacroix P, et al. [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76. French.

  [6]. Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24(7):838-40.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NW7524100 CHEMICAL NAME : Isoquinoline, 1-(3,4-diethoxybenzyl)-6,7-diethoxy-, hydrochloride CAS REGISTRY NUMBER : 985-13-7 LAST UPDATED : 199701 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C24-H29-N-O4.Cl-H MOLECULAR WEIGHT : 432.00 WISWESSER LINE NOTATION : T66 CNJ B1R CO2 DO2& HO2 FO2 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 660 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 5,69,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 86 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 9,585,1951 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5434 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1324 (estimated) No. of Female Employees: 667 (estimated)

安全

• 危险品运输编码: UN 3249
• 包装等级: II
• 危险类别: 6.1(a)
• 海关编码: 2933499090

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%