2975-34-0

• 常用中文名：Carphenazine Dimaleate
• 常用英文名：Carphenazine Dimaleate
• CAS号：2975-34-0
• 分子式：C₂₈H₃₅N₃O₆S
• 分子量：541.65900
• 发布时间：2016-04-05 20:47:29
• 更新时间：2025-08-23 21:03:11
• Carphenazine dimaleate is an antipsychotic agent, mainly used for the treatment of chronic schizophrenia.

名称

• 英文名: carphenazine maleate
• 英文别名: Proketazine; Proketazine dimaleate; (Z)-but-2-enedioic acid,1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]propan-1-one; Carphenazine dimaleate; EINECS 221-019-2; CARPHENAZINE MALEATE; Carfenazine hydrogen maleate; Procethazine dimaleate; Proketazine maleate; Carfenazine maleate

物化性质

• 沸点: 616.9ºC at 760 mmHg
• 分子式: C₂₈H₃₅N₃O₆S
• 分子量: 541.65900
• 闪点: 326.9ºC
• 精确质量: 541.22500
• PSA: 146.92000
• LogP: 3.53460
• 蒸汽压: 4.46E-16mmHg at 25°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:5

  3.氢键受体数量:14

  4.可旋转化学键数量:12

  5.互变异构体数量:2

  6.拓扑分子极性表面积:222

  7.重原子数量:46

  8.表面电荷:0

  9.复杂度:674

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:2

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:3

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UC2975000 CAS REGISTRY NUMBER : 2975-34-0 LAST UPDATED : 199707 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C24-H31-N3-O2-S.2C4-H4-O4 MOLECULAR WEIGHT : 657.80 WISWESSER LINE NOTATION : T C666 BN ISJ EV2 B3- AT6N DNTJ D2Q &OV1U1VO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 162 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,12,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 89 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,12,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 156 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,12,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 88 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,12,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,12,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,12,1972