154992-24-2

• 常用中文名：4-[3-(4-羟基丁基)-4,4-二甲基-2,5-二氧代-1-咪唑烷基]-2-(三氟甲基)苯腈
• 常用英文名：RU58841
• CAS号：154992-24-2
• 分子式：C₁₇H₁₈F₃N₃O₃
• 分子量：369.338
• 相关类别： 有机原料 有机氟化合物 氟苯腈系列
• 发布时间：2018-12-05 10:58:45
• 更新时间：2024-01-04 22:49:03
• RU 58841 (PSK-3841) 是雄激素受体拮抗剂,可促进头发再生。

名称

• 中文名: 4-[3-(4-羟基丁基)-4,4-二甲基-2,5-二氧代-1-咪唑烷基]-2-(三氟甲基)苯腈
• 英文名: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
• 中文别名: 4-[3-(4-羟基丁基)-4,4-二甲基-2,5-二氧代-1-咪唑啉]-2-(三氟甲基)苯甲腈
• 英文别名: Ru-58841; 4-(4,4-dimethyl-2,5-dioxo-3-(4-hydroxy-butyl)-1-imidazolidinyl)-2-(trifluoromethyl)-benzonitrile; 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile; Benzonitrile, 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)-; T5NVNV EHJ A4Q CR DCN CXFFF& E1 E1; 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile; RU58841; RU 58841

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 493.6±55.0 °C at 760 mmHg
• 分子式: C₁₇H₁₈F₃N₃O₃
• 分子量: 369.338
• 闪点: 252.3±31.5 °C
• 精确质量: 369.130035
• PSA: 84.64000
• LogP: 1.39
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.560
• 储存条件: 2-8°C

生物活性

• 描述: RU 58841 (PSK-3841) 是雄激素受体拮抗剂,可促进头发再生。
• 相关类别:
  信号通路 >> 其他 >> 雄激素受体
  研究领域 >> 内分泌
• 靶点:

  Androgen receptor

• 参考文献:

  [1]. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice By De Brouwer, B.; Tetelin, C.; Leroy, T.; Bonfils, A.; Van Neste, D. .From British Journal of Dermatology (1997), 137(5), 699-702.

  [2]. Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis ChC, Blume-Peytavi U, Sch?fer-Korting M.RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia.Pharmazie. 2005 Jan;60(1):8-12.

  [3]. Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D.RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism.J Steroid Biochem Mol Biol. 1994 Jan;48(1):55-60.

  [4]. Blaschke T, Kankate L, Kramer KD.Structure and dynamics of drug-carrier systems as studied by parelectric spectroscopy.Adv Drug Deliv Rev. 2007 Jul 10;59(6):403-10. Epub 2007 May 3.

  [5]. Matias JR, Gaillard M.Local inhibition of sebaceous gland growth by topically applied RU 58841.Ann N Y Acad Sci. 1995 Jun 12;761:56-65.

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

合成路线

4753-59-7 143782-20-1 ~77% 154992-24-2

文献：Leonard, Matthew J.; Lingham, Anthony R.; Niere, Julie O.; Jackson, Neale R. C.; McKay, Peter G.; Huegel, Helmut M. RSC Advances, 2014 , vol. 4, # 27 p. 14143 - 14148

654-70-6 ~% 154992-24-2

文献：RSC Advances, , vol. 4, # 27 p. 14143 - 14148

1259327-69-9 ~% 154992-24-2

文献：RSC Advances, , vol. 4, # 27 p. 14143 - 14148

上下游产品

上游产品  3
4753-59-7 143782-20-1 654-70-6
下游产品  1
4427-97-8

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%