95167-41-2

• 常用中文名：DY131
• 常用英文名：DY131
• CAS号：95167-41-2
• 分子式：C₁₈H₂₁N₃O₂
• 分子量：311.378
• 相关类别： 研究领域 癌症
• 发布时间：2017-03-27 14:35:49
• 更新时间：2024-01-07 18:19:49
• DY131(GSK 9089)是ERRβ和ERRγ选择性激动剂，对ERRα，ERα和ERβ的活性极低。

名称

• 中文名: DY131
• 英文名: DY131
• 英文别名: Benzoic acid, 4-hydroxy-, 2-[(1E)-[4-(diethylamino)phenyl]methylene]hydrazide; N'-{(E)-[4-(diethylamino)phenyl]methylidene}-4-hydroxybenzohydrazide; N'-{(E)-[4-(Diethylamino)phenyl]methylene}-4-hydroxybenzohydrazide; Benzoic acid, 4-hydroxy-, [[4-(diethylamino)phenyl]methylene]hydrazide (9CI); N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine; GSK 9089

物化性质

• 密度: 1.1±0.1 g/cm3
• 分子式: C₁₈H₂₁N₃O₂
• 分子量: 311.378
• 精确质量: 311.163391
• PSA: 64.93000
• LogP: 3.17
• 折射率: 1.574
• 储存条件: 2-8°C

生物活性

• 描述: DY131(GSK 9089)是ERRβ和ERRγ选择性激动剂,对ERRα,ERα和ERβ的活性极低。
• 相关类别:
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 癌症
• 参考文献:

  [1]. Wang Y, Arvanites AC, Davidow L,et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation . ACS Chem Biol. 2012,15;7(6):1040-8.

  [2]. Kumar P, Mendelson CR. Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation. Mol Endocrinol. 2011;25(9):1513-26.

  [3]. Yamamoto T, Mori T, Sawada M, et al. Estrogen-related receptor-γ regulates estrogen receptor-α responsiveness in uterine endometrial cancer. Int J Gynecol Cancer. 2012;22(9):1509-16.

  [4]. Yu S, Wang X, Ng CF, et al. ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res. 2007;67(10):4904-14.

  [5]. Donna D. Yu, Barry Marc Forman. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorganic & Medicinal Chemistry Letters. 2005,15(5): 1311-1313.

安全

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36
• 海关编码: 2928000090

合成路线

5351-23-5 120-21-8 ~66% 95167-41-2

文献：Forman, Barry; Yu, Donna Patent: US2006/189825 A1, 2006 ; Location in patent: Page/Page column 7; 12; Sheet 3/7 ; US 20060189825 A1

3290-99-1 ~% 95167-41-2

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 5 p. 1311 - 1313

120-21-8 ~% 95167-41-2

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 5 p. 1311 - 1313

123-08-0 120-21-8 ~% 95167-41-2

文献：Journal of Medicinal Chemistry, , vol. 48, # 9 p. 3107 - 3109

上下游产品

上游产品  4
5351-23-5 120-21-8 3290-99-1 123-08-0
下游产品  0

海关

海关编码	2928000090
中文概述	2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%