65009-35-0

• 常用中文名：盐酸利多卡因d3
• 常用英文名：Lidamidine hydrochloride
• CAS号：65009-35-0
• 分子式：C₁₁H₁₇ClN₄O
• 分子量：256.73
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 肾上腺素能受体
• 发布时间：2017-03-21 00:16:09
• 更新时间：2024-01-13 12:54:38
• 盐酸利达脒(WHR-1142A)是一种α2-肾上腺素能受体激动剂和止泻剂[1]。

名称

• 中文名: 盐酸利多卡因d3
• 英文名: 1-(2,6-dimethylphenyl)-3-[imino(methylamino)methyl]uronium chloride
• 英文别名: Einecs 265-307-6; LIDAMIDINE(LIDAMIDIUM) HYDROCHLORIDE; Unii-3Q1Q4qjv3v; 1-(2,6-Dimethylphenyl)-3-(N-methylcarbamimidoyl)urea hydrochloride (1:1); Lidamidine hydrochloride; 1-(2,6-Dimethylphenyl)-3-methylamidinourea hydrochloride; LIDAMIDINE HCL; Urea, N-(2,6-dimethylphenyl)-N'-[imino(methylamino)methyl]-, hydrochloride (1:1)

物化性质

• 沸点: 342.4ºC at 760 mmHg
• 分子式: C₁₁H₁₇ClN₄O
• 分子量: 256.73
• 闪点: 160.9ºC
• 精确质量: 256.109100
• PSA: 77.01000
• LogP: 3.33560

生物活性

• 描述: 盐酸利达脒(WHR-1142A)是一种α2-肾上腺素能受体激动剂和止泻剂[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
• 参考文献:

  [1]. DeLong AF, et al. Pharmacokinetics and disposition of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent, in rat and monkey. Arzneimittelforschung. 1978;28(8a):1477-80.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YU4995000 CHEMICAL NAME : Urea, 1-(2,6-xylyl)-3-methylamidino-, hydrochloride CAS REGISTRY NUMBER : 65009-35-0 LAST UPDATED : 199306 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C11-H16-N4-O.Cl-H MOLECULAR WEIGHT : 256.77 WISWESSER LINE NOTATION : MUYM1&MVMR B1 F1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 187 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - urine volume increased REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 303 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - urine volume increased REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 65 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 300 mg/kg/30D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Endocrine - hyperglycemia Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 1140 mg/kg/38D-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978