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2615-15-8生产厂家

2615-15-8价格

相关CAS号：
2615-15-8 1072-40-8
23601-40-3 14260-95-8
24342-68-5 3055-96-7
72713-23-6 42749-27-9
155887-96-0 94376-75-7

2615-15-8

2615-15-8结构式
2615-15-8结构式

化源商城直购

中文名 六甘醇
英文名 hexaethylene glycol
中文别名 六乙烯二醇
六乙二醇
六聚乙二醇
英文别名 EINECS 220-045-1
HEXAETHYLENE GLYCOL
Polyethylene glycol 300
MFCD00002877
3,6,9,12,15-Pentaoxaheptadecane-1,17-diol
hexa-PEG-diol
2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
hexaethyleneglycol
PEG-6
Hexagol
Hexaoxyethylene glycol
描述 Hexaethylene glycol 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。
相关类别
靶点

PEGs
体外研究 PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。
参考文献

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
密度 1.1±0.1 g/cm3
沸点 378.3±0.0 °C at 760 mmHg
熔点 5-7 °C(lit.)
分子式 C12H26O7
分子量 282.331
闪点 193.7±26.5 °C
精确质量 282.167847
PSA 86.61000
LogP -2.95
蒸汽压 0.0±1.9 mmHg at 25°C
折射率 1.460
储存条件

密封于阴凉干燥环境。
稳定性

如果遵照规格使用和储存则不会分解。
分子结构

1、 摩尔折射率：69.43

2、 摩尔体积（cm3/mol）：253.4

3、 等张比容（90.2K）：641.3

4、 表面张力（dyne/cm）：41.0

5、 极化率（10-24cm3）：27.52
计算化学

1.疏水参数计算参考值（XlogP）:-1.9

2.氢键供体数量:2

3.氢键受体数量:7

4.可旋转化学键数量:16

5.互变异构体数量:无

6.拓扑分子极性表面积86.6

7.重原子数量:19

8.表面电荷:0

9.复杂度:141

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1
更多

1. 性状：无可用

2. 密度（g/mL,25/4℃）：1.127

3. 相对蒸汽密度（g/mL,空气=1）：无可用

4. 熔点（ºC）：5-7

5. 沸点（ºC,常压）：217

6. 沸点（ºC,5.2kPa）：无可用

7. 折射率：1.465

8. 闪点（ºC）：>110

9. 比旋光度（º）：无可用

10. 自燃点或引燃温度（ºC）：无可用

11. 蒸气压（kPa,25ºC）：无可用

12. 饱和蒸气压（kPa,60ºC）：无可用

13. 燃烧热（KJ/mol）：无可用

14. 临界温度（ºC）：无可用

15. 临界压力（KPa）：无可用

16. 油水（辛醇/水）分配系数的对数值：无可用

17. 爆炸上限（%,V/V）：无可用

18. 爆炸下限（%,V/V）： 无可用

19. 溶解性：无可用
Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name: Hexaethylene glycol
CAS-No.: 2615-15-8
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances


Section2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogramnone
Signal wordnone
Hazard statement(s)none
Precautionary statement(s) none
Supplemental Hazardnone
Statements
The following percentage of the mixture consists of ingredient(s) with unknown acute toxicity: 100 %
The following percentage of the mixture consists of ingredient(s) with unknown hazards to the aquatic
environment: 100 %
Other hazards - none
Section3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Synonyms: 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol
Formula: C12H26O7
Molecular Weight: 282,33 g/mol
Section4. FIRST AID MEASURES
Description of first aid measures
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact
Wash off with soap and plenty of water.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water.
Most important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
no data available
Section5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available
Section6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Avoid breathing vapors, mist or gas.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
Section7. HANDLING AND STORAGE
Precautions for safe handling
Normal measures for preventive fire protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Specific end uses
no data available
Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
General industrial hygiene practice.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards
such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK
(EU EN 14387) respirator cartridges. Use respirators and components tested and approved under
appropriate government standards such as NIOSH (US) or CEN (EU).
Section9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) AppearanceForm: liquid, clear, viscous
Colour: light yellow
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezingMelting point/range: 5 - 7 °C - lit.
point
f) Initial boiling point and 217 °C at 5 hPa - lit.
boiling range
g) Flash point> 113,00 °C - closed cup
h) Evaporation rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative density1,127 g/mL at 25 °C
n) Water solubilityno data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available
Section10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
Section11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 32.000 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity). Gastrointestinal:Other changes. Kidney,
Ureter, Bladder:Other changes.
Skin corrosion/irritation
Serious eye damage/eye irritation
Eyes - rabbit - Mild eye irritation
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Specific target organ toxicity - single exposure
Specific target organ toxicity - repeated exposure
Aspiration hazard
Potential health effects
InhalationMay be harmful if inhaled. May cause respiratory tract irritation.
IngestionMay be harmful if swallowed.
SkinMay be harmful if absorbed through skin. May cause skin irritation.
EyesMay cause eye irritation.
Additional Information
RTECS: MM3670000
Section12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
Mobility in soil
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available
Section13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.
Section14. TRANSPORT INFORMATION
UN number
ADR/RID: -IMDG: -IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA:Not dangerous goods
Transport hazard class(es)
ADR/RID: -IMDG: -IATA: -
Packaging group
ADR/RID: -IMDG: -IATA: -
Environmental hazards
ADR/RID: noIMDG Marine pollutant: noIATA: no
Special precautions for user
no data available
Section15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available
Section16. OTHER INFORMATION
Further information
Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

毒理学数据:

急性毒性：

口腔 LD50 20mg/kg(guinea pig)

32mg/kg(rat)

刺激眼睛 mid 500mg(rbt)

主要的刺激性影响：

在皮肤上面：可能引起发炎

在眼睛上面：可能引起发炎

致敏作用：没有已知的敏化影响。

生态学数据:

总括注解

水危害级别1（德国规例）（通过名单进行自我评估）该物质对水有稍微危害的。

不要让未稀释或大量的产品接触地下水、水道或污水系统。

若无政府许可，勿将材料排入周围环境。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MM3670000
CHEMICAL NAME :
Hexaethylene glycol
CAS REGISTRY NUMBER :
2615-15-8
BEILSTEIN REFERENCE NO. :
1638281
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C12-H26-O7
MOLECULAR WEIGHT :
282.38
WISWESSER LINE NOTATION :
Q2/O2/ 5Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
32 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
20 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

个人防护装备 Eyeshields;Gloves
危害码 (欧洲) Xn
安全声明 (欧洲) S23-S24/25
危险品运输编码 NONH for all modes of transport
WGK德国 2
RTECS号 MM3670000
海关编码 2909499000
海关编码 2909499000
中文概述 2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
申报要素 品名, 成分含量, 用途
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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