CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DK7175000
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CHEMICAL NAME :
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p-Benzoquinone, 2,3,5-tris(1-aziridinyl)-
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CAS REGISTRY NUMBER :
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68-76-8
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BEILSTEIN REFERENCE NO. :
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0238057
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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98
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MOLECULAR FORMULA :
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C12-H13-N3-O2
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MOLECULAR WEIGHT :
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231.28
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WISWESSER LINE NOTATION :
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L6V DVJ B- AT3NTJ& C- AT3NTJ& E- AT3NTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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500 ug/kg
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TOXIC EFFECTS :
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Blood - leukopenia
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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500 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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500 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1560 ug/kg/1Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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125 ug/kg
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SEX/DURATION :
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female 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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1 mg/kg
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SEX/DURATION :
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female 1 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - oogenesis
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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125 ug/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - germ cell effects (in offspring)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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20 ug/kg
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SEX/DURATION :
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female 15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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125 ug/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetal death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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125 ug/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
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TYPE OF TEST :
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Specific locus test
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Heritable translocation test
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Micronucleus test
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
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Micronucleus test
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TYPE OF TEST :
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DNA inhibition
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TYPE OF TEST :
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DNA inhibition
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
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Sister chromatid exchange
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TYPE OF TEST :
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Sister chromatid exchange
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Sperm Morphology
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TYPE OF TEST :
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Heritable translocation test
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TYPE OF TEST :
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Micronucleus test
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TYPE OF TEST :
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Micronucleus test
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
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Sister chromatid exchange
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TYPE OF TEST :
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Sister chromatid exchange
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TYPE OF TEST :
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Micronucleus test
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TYPE OF TEST :
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Micronucleus test
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TYPE OF TEST :
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Micronucleus test
MUTATION DATA
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TYPE OF TEST :
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DNA damage
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TEST SYSTEM :
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Mammal - species unspecified Lymphocyte
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DOSE/DURATION :
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14 mmol/L
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 65,21,1979 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,67,1975 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,67,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,367,1987 TOXICOLOGY REVIEW ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 28,135,1971
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