CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DK8180000
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CHEMICAL NAME :
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2H-1,2,4-Benzothiadiazine-3-carboxylic acid, 7-(aminosulfonyl)-6-chloro-3,4-dihydro- 2-methyl-, methyl ester, 1,1-dioxide
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CAS REGISTRY NUMBER :
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42583-55-1
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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9
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MOLECULAR FORMULA :
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C10-H12-Cl-N3-O6-S2
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MOLECULAR WEIGHT :
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369.82
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WISWESSER LINE NOTATION :
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T66 BSWN EM DHJ C1 DVO1 HG ISZW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>10 gm/kg
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - urine volume increased
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>5 gm/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - urine volume increased
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>5 gm/kg
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - urine volume increased
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REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>10 gm/kg
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - urine volume increased
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REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
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TYPE OF TEST :
-
LD - Lethal dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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>5 gm/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - urine volume increased
-
REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
-
TYPE OF TEST :
-
LD - Lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
>5 gm/kg
-
TOXIC EFFECTS :
-
Kidney, Ureter, Bladder - urine volume increased
-
REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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6 gm/kg
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SEX/DURATION :
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female 9-14 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1500 mg/kg
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SEX/DURATION :
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female 9-14 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - musculoskeletal system
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REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1500 mg/kg
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SEX/DURATION :
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female 7-12 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - musculoskeletal system
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973
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