168828-58-8

• 常用中文名：Sutezolid
• 常用英文名：Sutezolid
• CAS号：168828-58-8
• 分子式：C₁₆H₂₀FN₃O₃S
• 分子量：353.41200
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2017-03-09 17:03:05
• 更新时间：2024-01-11 09:09:54
• Sutezolid(PNU-100480)是一种恶唑烷酮类抗菌剂,用于治疗结核病。

名称

• 中文名: Sutezolid
• 英文名: N-[[(5S)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• 英文别名: (S)-N-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide; N[[(5S)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide; Sutezolid [USAN]; N-{[3-(3-Fluoro-4-(1,4-thiazaperhydroin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide; Sutezolid; Sutezolid [INN]

物化性质

• 密度: 1.321g/cm3
• 沸点: 609ºC at 760 mmHg
• 分子式: C₁₆H₂₀FN₃O₃S
• 分子量: 353.41200
• 闪点: 322.1ºC
• 精确质量: 353.12100
• PSA: 87.18000
• LogP: 2.36110
• 蒸汽压: 8.97E-15mmHg at 25°C
• 折射率: 1.584
• 储存条件: 2-8℃

生物活性

• 描述: Sutezolid(PNU-100480)是一种恶唑烷酮类抗菌剂,用于治疗结核病。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Zhu T, et al. Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular Mycobacterium tuberculosis in ex vivo whole-blood cultures ofpatients with pulmonary

  [2]. Wallis RS, et al. Mycobactericidal activity of sutezolid (PNU-100480) in sputum (EBA) and blood (WBA) of patients with pulmonary tuberculosis. PLoS One. 2014 Apr 14;9(4):e94462.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危险品运输编码: NONH for all modes of transport

合成路线

369-34-6 ~% 168828-58-8

文献：Barbachyn, Michael R.; Hutchinson, Douglas K.; Brickner, Steven J.; Cynamon, Michael H.; Kilburn, James O.; et al. J. Med. Chem., 1996 , vol. 39, # 3 p. 680 - 685

168828-70-4 ~% 168828-58-8

文献：Barbachyn, Michael R.; Hutchinson, Douglas K.; Brickner, Steven J.; Cynamon, Michael H.; Kilburn, James O.; et al. J. Med. Chem., 1996 , vol. 39, # 3 p. 680 - 685

237432-11-0 ~% 168828-58-8

文献：Barbachyn, Michael R.; Hutchinson, Douglas K.; Brickner, Steven J.; Cynamon, Michael H.; Kilburn, James O.; et al. J. Med. Chem., 1996 , vol. 39, # 3 p. 680 - 685

168828-72-6 ~% 168828-58-8

文献：Barbachyn, Michael R.; Hutchinson, Douglas K.; Brickner, Steven J.; Cynamon, Michael H.; Kilburn, James O.; et al. J. Med. Chem., 1996 , vol. 39, # 3 p. 680 - 685

168828-71-5 ~% 168828-58-8

文献：Barbachyn, Michael R.; Hutchinson, Douglas K.; Brickner, Steven J.; Cynamon, Michael H.; Kilburn, James O.; et al. J. Med. Chem., 1996 , vol. 39, # 3 p. 680 - 685

168828-74-8 ~% 168828-58-8

文献：Barbachyn, Michael R.; Hutchinson, Douglas K.; Brickner, Steven J.; Cynamon, Michael H.; Kilburn, James O.; et al. J. Med. Chem., 1996 , vol. 39, # 3 p. 680 - 685

108-24-7 216869-36-2 ~% 168828-58-8

文献：Barbachyn, Michael R.; Hutchinson, Douglas K.; Brickner, Steven J.; Cynamon, Michael H.; Kilburn, James O.; et al. J. Med. Chem., 1996 , vol. 39, # 3 p. 680 - 685

上下游产品

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369-34-6 168828-70-4 237432-11-0 168828-72-6
168828-71-5 168828-74-8 108-24-7
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