7174-27-8

• 常用中文名：鸭嘴花碱盐酸盐
• 常用英文名：Vasicine hydrochloride
• CAS号：7174-27-8
• 分子式：C₁₁H₁₃ClN₂O
• 分子量：224.68700
• 相关类别： 研究领域 感染
• 发布时间：2018-09-15 21:46:29
• 更新时间：2025-08-27 16:52:01
• Vasicine hydrochloride (peganine hydrochloride) 是一种喹唑啉类生物碱,可从Justicia adhatoda 中分离得到。Vasicine (peganine) 具有抗结核活性。

名称

• 中文名: 鸭嘴花碱盐酸盐
• 英文名: (3S)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol,hydrochloride
• 英文别名: Peganine monohydrochloride; linarinehydrochloride; Vasicine Hcl

物化性质

• 沸点: 373.8ºC at 760 mmHg
• 熔点: 206-208ºC
• 分子式: C₁₁H₁₃ClN₂O
• 分子量: 224.68700
• 闪点: 179.9ºC
• 精确质量: 224.07200
• PSA: 35.83000
• LogP: 1.47230
• 储存条件: 室温

生物活性

• 描述: Vasicine hydrochloride (peganine hydrochloride) 是一种喹唑啉类生物碱,可从Justicia adhatoda 中分离得到。Vasicine (peganine) 具有抗结核活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50(1):49-53.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UY9454100 CHEMICAL NAME : Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro-, monohydrochloride, (R)- CAS REGISTRY NUMBER : 7174-27-8 LAST UPDATED : 199510 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C11-H12-N2-O.Cl-H MOLECULAR WEIGHT : 224.71 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 640 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 115 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 335 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 290 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 78200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 49(3),37,1986

合成路线

158734-31-7 ~% 7174-27-8

文献：Dhar, K. L.; Jain, M. P.; Koul, S. K.; Atal, C. K. Phytochemistry (Elsevier), 1981 , vol. 20, p. 319 - 322

6159-56-4 ~% 7174-27-8

文献：Dhar, K. L.; Jain, M. P.; Koul, S. K.; Atal, C. K. Phytochemistry (Elsevier), 1981 , vol. 20, p. 319 - 322

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