189224-48-4

• 常用中文名：2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑
• 常用英文名：KU14R
• CAS号：189224-48-4
• 分子式：C₁₃H₁₄N₂O
• 分子量：214.263
• 相关类别： 生物化工 抑制剂 蛋白酪氨酸激酶
• 发布时间：2016-07-22 20:21:44
• 更新时间：2024-01-08 17:53:59
• KU14R是胰岛素受体拮抗剂,能选择性阻断由咪唑啉引起的胰岛素分泌。

名称

• 中文名: 2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑
• 英文名: 2-(2-ethyl-3H-1-benzofuran-2-yl)-1H-imidazole
• 英文别名: cs-1007; 1H-Imidazole, 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-; hms3267m22; ku14r; 2-(2-Ethyl-2,3-dihydro-1-benzofuran-2-yl)-1H-imidazole

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 428.1±34.0 °C at 760 mmHg
• 熔点: 137-139ºC
• 分子式: C₁₃H₁₄N₂O
• 分子量: 214.263
• 闪点: 154.4±15.9 °C
• 精确质量: 214.110611
• PSA: 37.91000
• LogP: 2.10
• 外观性状: 白色固体
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.595
• 储存条件: Store at RT

生物活性

• 描述: KU14R是胰岛素受体拮抗剂,能选择性阻断由咪唑啉引起的胰岛素分泌。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Bozdagi O, Wang XB, Martinelli GP, et al. Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors. J Neurophysiol. 2011,105(3):1266-75.

  [2]. Bleck C, Wienbergen A, Rustenbeck I. Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R. Diabetologia. 2

  [3]. Cooper EJ, Hudson AL, Parker CA, et al. Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol. 2003;482(1-3):189-96.

  [4]. Mayer G, Taberner PV. Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse. Eur J Pharmacol. 2002;454(1):95-102.

  [5]. Susan L.F Chana, Anna L Palletta, John Clewsb. Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with σ receptors. European Journal of Pharmacology. 1997,323( 2-3): 241-244.