59865-15-5

• 常用中文名：二氢环孢菌素A
• 常用英文名：Dihydro Cyclosporin A
• CAS号：59865-15-5
• 分子式：C₆₂H₁₁₃N₁₁O₁₂
• 分子量：1204.627
• 相关类别： 研究领域 感染
• 发布时间：2018-03-02 08:00:00
• 更新时间：2024-01-20 12:01:16
• Dihydrocyclosporin A 是 Cyclosporine A (HY-B0579) 的衍生物。Dihydrocyclosporin A 对原鞭毛菌和胞内无尾鞭毛菌均有明显抑制作用。Dihydrocyclosporin A 具有高度的细胞毒性。

名称

• 中文名: 二氢环孢菌素A
• 英文名: Dihydro Cyclosporin A
• 中文别名: 双氢环孢菌素A; 环孢素杂质 B
• 英文别名: 6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A; <DH-MeBmt>cyclosporin; dihydro-CSA; DIHYDROCYCLOSPORIN A; Dihydrocyclosporin; (3S,6S,9S,12R,15S,18S,21S,24S,30S)-30-Ethyl-33-[(1R,2R)-1-hydroxy-2-methylhexyl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; (3R,4R)-3-Hydroxy-N-methyl-5-propylcyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-); (3R,4R)-3-Hydroxy-4,N-dimethyl-5-propylcyclo[L-Nva-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-]; 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 30-ethyl-33-[(1R,2R)-1-hydroxy-2-methylhexyl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-, (3S,6S,9S,12R,15S,18S,21S,24S,30S)-; Cyclosporin Impurity 10

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 1285.3±65.0 °C at 760 mmHg
• 熔点: 120-125ºC
• 分子式: C₆₂H₁₁₃N₁₁O₁₂
• 分子量: 1204.627
• 闪点: 731.1±34.3 °C
• 精确质量: 1203.857056
• PSA: 278.80000
• LogP: 3.67
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.465
• 储存条件: -20°C

生物活性

• 描述: Dihydrocyclosporin A 是 Cyclosporine A (HY-B0579) 的衍生物。Dihydrocyclosporin A 对原鞭毛菌和胞内无尾鞭毛菌均有明显抑制作用。Dihydrocyclosporin A 具有高度的细胞毒性。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Zheng ZW, et al. Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A. Parasit Vectors. 2020 Feb 21;13(1):94.

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