57021-61-1

• 常用中文名：异尼辛
• 常用英文名：isonixin
• CAS号：57021-61-1
• 分子式：C₁₄H₁₄N₂O₂
• 分子量：242.27300
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-06-25 17:36:31
• 更新时间：2024-01-10 14:45:51
• Isonixin(Isonixine)是一种非甾体化合物。Isonixin可用于疼痛和炎症的研究[1][2][3][4]。

名称

• 中文名: 异尼辛
• 英文名: isonixin
• 英文别名: Nixyn hermes; N-(2,6-Dimethylphenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide; Nixyn; 1,2-Dihydro-2-oxo-N-(2,6-xylyl)-3-pyridinecarboxamide; Isonixine

物化性质

• 密度: 1.244g/cm3
• 沸点: 520.5ºC at 760 mmHg
• 分子式: C₁₄H₁₄N₂O₂
• 分子量: 242.27300
• 闪点: 217.5ºC
• 精确质量: 242.10600
• PSA: 61.96000
• LogP: 2.31700
• 折射率: 1.628

生物活性

• 描述: Isonixin(Isonixine)是一种非甾体化合物。Isonixin可用于疼痛和炎症的研究[1][2][3][4]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体内研究: 异烟碱可延长小鼠的己巴比妥睡眠时间,减少运动活动,拮抗心梗诱发的惊厥,引起体温过高,并抑制震颤素诱发的颤抖[1]。异烟碱(p.o.)显示出3.15小时的吸收半衰期,并在胃肠道中迅速吸收[2]。异烟碱(静脉注射、胃内注射和十二指肠内注射)主要通过尿液排泄,异烟碱可在50小时内被尿液清除[3]。异烟碱(2000 mg/kg；每天口服一次,持续6个月)对雄性兔子和大鼠有轻微的毒性作用,不会引起胃肠道损伤[4]。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : US4600000 CHEMICAL NAME : 3-Pyridinecarboxamide, 1,2-dihydro-2-oxo-N-(2,6-xylyl)- CAS REGISTRY NUMBER : 57021-61-1 LAST UPDATED : 199210 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C14-H14-N2-O2 MOLECULAR WEIGHT : 242.30 WISWESSER LINE NOTATION : T6MVJ CVMR B1 F1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 281 gm/kg/26W-I TOXIC EFFECTS : Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1460,1977