633-03-4

• 常用中文名：亮绿
• 常用英文名：Brilliant Green
• CAS号：633-03-4
• 分子式：C₂₇H₃₄N₂O₄S
• 分子量：482.635
• 相关类别： 染料及颜料 染料 碱性染料
• 发布时间：2018-03-11 08:00:00
• 更新时间：2024-01-02 19:34:49
• 亮绿色是一种阳离子染料,用于给丝绸和羊毛上色。明亮的绿色可以抑制霉菌、肠道寄生虫和真菌的繁殖。亮绿色对革兰氏阳性菌有效[1][2]。

名称

• 中文名: 碱性绿 1
• 英文名: Brilliant green
• 中文别名: 碱性亮绿1/灿烂绿; 亮绿; 盐基金沙绿; 碱性亮绿; 灿烂绿
• 英文别名: Brilliant Green; N-(4-{[4-(Diethylamino)phenyl](phenyl)methyliden}cyclohexa-2,5-dien-1-yliden)-N-ethylethanaminiumhydrogen-_sulfat; EINECS 211-190-1; 4-{[4-(Diethylamino)phenyl](phenyl)methylene}-N,N-diethyl-2,5-cyclohexadien-1-iminium hydrogen sulfate; Brillant green; MFCD00011880; N-(4-{[4-(Diethylamino)phenyl](phenyl)methylene}-2,5-cyclohexadien-1-ylidene)-N-ethylethanaminium hydrogen sulfate; Brilliant Green G; EMERALD GREEN; 4,4'-bis-diethylamino-tritylium,hydrogen sulfate; N-(4-{[4-(diethylamino)phenyl](phenyl)methylidene}cyclohexa-2,5-dien-1-ylidene)-N-ethylethanaminium hydrogen sulfate; N-(4-{[4-(Diethylamino)phenyl](phenyl)methylene}cyclohexa-2,5-dien-1-ylidene)-N-ethylethanaminium hydrogen sulfate; Diamond Green G; Malachite Green G

物化性质

• 熔点: 210 °C (dec.)(lit.)
• 分子式: C₂₇H₃₄N₂O₄S
• 分子量: 482.635
• 精确质量: 482.223938
• PSA: 92.29000
• LogP: 6.48360
• 外观性状: 金属绿色晶体
• 储存条件:

  存放在密封容器内，并放在阴凉，干燥处。储存的地方必须远离氧化剂。

• 稳定性:

  远离氧化物

• 水溶解性: 100 G/L (25 ºC)
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:5

  4.可旋转化学键数量:7

  5.互变异构体数量:无

  6.拓扑分子极性表面积92.1

  7.重原子数量:34

  8.表面电荷:0

  9.复杂度:642

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  1. 性状：金色闪光的细结晶。

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）： 210

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于水和乙醇呈绿色。

生物活性

• 描述: 亮绿色是一种阳离子染料,用于给丝绸和羊毛上色。明亮的绿色可以抑制霉菌、肠道寄生虫和真菌的繁殖。亮绿色对革兰氏阳性菌有效[1][2]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Nandi BK, et al. Adsorption characteristics of brilliant green dye on kaolin. J Hazard Mater. 2009 Jan 15;161(1):387-95.

  [2]. Narat JK. BRILLIANT GREEN: A CLINICAL STUDY OF ITS VALUE AS A LOCAL ANTISEPTIC. Ann Surg. 1931 Dec;94(6):1007-12.

MSDS

Name: Brilliant Green High Purity Biological Stain Material Safety Data Sheet Synonym: C.I. 42040; Malachite Green G; Ethyl Green; Emerald Green; Diamond Green G; Fast Green J; Solid Gree CAS: 633-03-4 Section 1 - Chemical Product MSDS Name:Brilliant Green High Purity Biological Stain Material Safety Data Sheet Synonym:C.I. 42040; Malachite Green G; Ethyl Green; Emerald Green; Diamond Green G; Fast Green J; Solid Gree Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 633-03-4 Brilliant Green 100 211-190-1 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Hygroscopic (absorbs moisture from the air). Potential Health Effects Eye: This product contains a cationic dye. Similar dyes have caused permanent injury to the cornea and conjunctiva in documented exposure cases with human or rabbit eyes. Skin: Causes skin irritation. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. SPEEDY ACTION IS CRITICAL! Skin: Get medical aid if irritation develops or persists. Wash clothing before reuse. Flush skin with plenty of soap and water. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Extinguishing Media: Use alcohol foam, carbon dioxide, or water spray when fighting fires involving this material. In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Do not ingest or inhale. Wash clothing before reuse. Storage: Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 633-03-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: green Odor: odorless pH: Not available. Vapor Pressure: Negligible. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Decomposes. Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: 210 deg C Solubility in water: Moderately soluble in water. Specific Gravity/Density: Not available. Molecular Formula: C27H33N2.HSO4 Molecular Weight: 385.2444 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, moisture. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide, nitrogen. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 633-03-4: BP6825000 LD50/LC50: Not available. Carcinogenicity: Brilliant Green - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Other No information available. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 633-03-4: 2 Canada CAS# 633-03-4 is listed on Canada's DSL List. CAS# 633-03-4 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 633-03-4 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1 、急性毒性：小鼠（腹膜）LDLo： 5mg/kg 小鼠（静脉）LDLo： 3mg/kg 大鼠（口服）LDLo：10mg/kg 大鼠（腹膜）LDLo： 8mg/kg 豚鼠（腹膜）LDLo： 3mg/kg 由于食盐的LD50是3,000 mg/kg，BPA的急性毒性程度与食盐同。 生态学数据: 对水稍微有危害的，不要让未稀释或者大量产品接触地下水，水道或者污水系统。若无政府许可，勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : BP6825000 CAS REGISTRY NUMBER : 633-03-4 LAST UPDATED : 199706 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C27-H33-N2.H-O4-S MOLECULAR WEIGHT : 482.69 WISWESSER LINE NOTATION : L6Y DYJ AUYR&R DN2&2& DUK2&2 &Q &S-O4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Human TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - guinea pig TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - emphysema Gastrointestinal - necrotic changes Liver - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 3 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 104 mg/m3/6W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 100 ug/L REFERENCE : VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #542-84 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2187 No. of Facilities: 581 (estimated) No. of Industries: 12 No. of Occupations: 14 No. of Employees: 7268 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2187 No. of Facilities: 1486 (estimated) No. of Industries: 16 No. of Occupations: 22 No. of Employees: 43142 (estimated) No. of Female Employees: 29395 (estimated)

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H319
• 警示性声明: P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R22;R36
• 安全声明 (欧洲): S26-S39
• 危险品运输编码: 2811
• WGK德国: 3
• RTECS号: BP6825000
• 包装等级: II
• 危险类别: 6.1(a)

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制备

采用缩合法，将N，N-二甲基苯胺在硫酸、尿素存在下与苯甲醛缩合，加入次氯酸钠氧化，再用草酸酸溶，最后经结晶、干燥、混合而得。

由N,N-二乙基苯胺与苯甲醛在尿素存在下进行缩合，再用二氧化铅和盐酸进行氧化，而后用硫酸钠脱铅，用碳酸钠中和，用硫酸溶解、结晶，过滤及干燥即得成品。原料消耗(kg/t)N,N-二乙基苯胺 515苯甲醛 325二氧化铅 745