193746-75-7

• 常用中文名：4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶
• 常用英文名：SB 242235
• CAS号：193746-75-7
• 分子式：C₁₉H₂₀FN₅O
• 分子量：353.393
• 相关类别： 信号通路 MAPK/ERK信号通路 p38 MAPK
• 发布时间：2016-08-13 16:41:35
• 更新时间：2024-01-10 14:14:37
• SB-242235是p38 MAP激酶抑制剂,IC50为1.0 uM。

名称

• 中文名: 4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶
• 英文名: 4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-methoxypyrimidine
• 英文别名: 4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine; Kinome_3169; HMS3244I17; HMS3244I18; HMS3244J17; 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-2-methoxypyrimidine; 4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine; Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-; SB 242235

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 568.4±60.0 °C at 760 mmHg
• 分子式: C₁₉H₂₀FN₅O
• 分子量: 353.393
• 闪点: 297.5±32.9 °C
• 精确质量: 353.165192
• PSA: 64.86000
• LogP: 3.01
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.662
• 储存条件: 2-8℃

生物活性

• 描述: SB-242235是p38 MAP激酶抑制剂,IC50为1.0 uM。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 癌症
• 参考文献:

  [1]. Badger, A.M., et al., Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures. Osteoarthritis Cartilage, 2000. 8(6): p. 434-43.

  [2]. Ward, K.W., et al., SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics. Xenobiotica, 2002. 32(3): p. 221-33.

  [3]. Kim, A.L., et al., Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J Invest Dermatol, 2005. 124(6): p. 1318-25.

  [4]. Ward, K.W., et al., SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: in vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man. Xenobiotica, 2002. 32(3): p. 235-50.