543-15-7

• 常用中文名：6-氨基-2-甲基-2-庚醇盐酸盐
• 常用英文名：6-amino-2-methylheptan-2-ol,hydrochloride
• CAS号：543-15-7
• 分子式：C₈H₂₀ClNO
• 分子量：181.70300
• 相关类别： 生物化工 氨基酸及其衍生物 氨基醇类衍生物
• 发布时间：2018-08-31 21:59:29
• 更新时间：2024-01-12 11:09:16
• Heptaminol盐酸盐是一种血管收缩剂, 用于治疗低血压, 特别是体位性低血压。

名称

• 中文名: 盐酸庚胺醇
• 英文名: 6-amino-2-methylheptan-2-ol,hydrochloride
• 中文别名: 酸庚胺醇; 6-氨基-2-甲基-2-庚醇盐酸盐
• 英文别名: 6-hydroxy-6-methyl-2-heptylamine hydrochloride; Heptylon tropfen; 6-amino-2-methyl-2-heptanol hydrochloride; Heptamyl tropfen; Coreptil; MFCD00013015; 6-Amino-2-methyl-heptan-2-ol,Hydrochlorid; Delmiton; Arcor tropfen; Cardiosintol; Heptaminol HCl; Cortensor; EINECS 208-837-5; 6-amino-2-methyl-heptan-2-ol,hydrochloride; heptaminol hydrochloride

物化性质

• 密度: 0.895g/cm3
• 沸点: 250.1ºC at 760mmHg
• 熔点: 165-167 °C(lit.)
• 分子式: C₈H₂₀ClNO
• 分子量: 181.70300
• 闪点: 105.1ºC
• 精确质量: 181.12300
• PSA: 46.25000
• LogP: 2.77710
• 储存条件:

  储存于阴凉、干燥、通风良好的库房。远离火种、热源。防止阳光直射。包装密封。应与酸类、食用化学品分开存放，切忌混储。储区应备有合适的材料收容泄漏物。

• 稳定性:

  按规格使用和贮存，不会发生分解，避免与氧化物接触

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:3

  3.氢键受体数量:2

  4.可旋转化学键数量:4

  5.互变异构体数量:无

  6.拓扑分子极性表面积46.2

  7.重原子数量:11

  8.表面电荷:0

  9.复杂度:91.3

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  1. 性状：未确定

  2. 密度（g/ cm³,25/4℃）：未确定

  3. 相对蒸汽密度（g/cm³,空气=1）：未确定

  4. 熔点（ºC）：165-167

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,66.70kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºF）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,55.1ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: Heptaminol盐酸盐是一种血管收缩剂, 用于治疗低血压, 特别是体位性低血压。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Pourrias B, et al. Heptaminol chlorhydrate: new data. Ann Pharm Fr. 1991;49(3):127-138.

MSDS

Name: 6-Amino-2-Methyl-2-Heptanol Hydrochloride 98+% (Titr.) Material Safety Data Sheet Synonym: Heptaminol Hydrochloride; Heptaminyl Hydrochloride; 2-Heptylamine CAS: 543-15-7 Section 1 - Chemical Product MSDS Name:6-Amino-2-Methyl-2-Heptanol Hydrochloride 98+% (Titr.) Material Safety Data Sheet Synonym:Heptaminol Hydrochloride; Heptaminyl Hydrochloride; 2-Heptylamine Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 543-15-7 6-Amino-2-methyl-2-heptanol hydrochlor 100.0 208-837-5 Hazard Symbols: XN Risk Phrases: 22 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful if swallowed.The toxicological properties of this material have not been fully investigated.Hygroscopic (absorbs moisture from the air). Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 543-15-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white to off-white Odor: odorless pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 160 - 165 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: soluble Specific Gravity/Density: Molecular Formula: C8H19NO.HCl Molecular Weight: 145.1391 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, exposure to moist air or water. Incompatibilities with Other Materials: Strong oxidizing agents, strong bases. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 543-15-7: MJ3240000 LD50/LC50: Not available. Carcinogenicity: 6-Amino-2-methyl-2-heptanol hydrochloride - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. Safety Phrases: WGK (Water Danger/Protection) CAS# 543-15-7: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 543-15-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 543-15-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、急性毒性：人经口TDLo：28ug/kg，心脏-脉率增加，没有下降的B，P肾、输尿管、膀胱-尿量增加，皮肤及附件-出汗； 小鼠经腹腔LD50：900mg/kg，除致死剂量外无详细说明； 豚鼠经未知途径LDLo：670mg/kg，除致死剂量外无详细说明； 生态学数据: 该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : MJ3240000 CHEMICAL NAME : 2-Heptanol, 6-amino-2-methyl-, hydrochloride CAS REGISTRY NUMBER : 543-15-7 LAST UPDATED : 199012 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C8-H19-N-O.Cl-H MOLECULAR WEIGHT : 181.74 WISWESSER LINE NOTATION : ZY1&3XQ1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 28 ug/kg TOXIC EFFECTS : Cardiac - pulse rate increase, without fall in BP Kidney, Ureter, Bladder - urine volume increased Skin and Appendages - sweating REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,178,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,178,1951 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 670 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,515,1970

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): S22-S24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: MJ3240000
• 海关编码: 2922199090

海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%