91-84-9

• 常用中文名：美吡拉敏
• 常用英文名：PYRILAMINE
• CAS号：91-84-9
• 分子式：C₁₇H₂₃N₃O
• 分子量：285.38400
• 相关类别： 原料药 抗变态反应药 抗组胺药
• 发布时间：2018-09-05 07:27:05
• 更新时间：2024-01-04 18:28:01
• Mepyramine, a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.

名称

• 中文名: 美吡拉敏
• 英文名: mepyramine
• 英文别名: [13C]-Pyrilamine; Neoantergan; Antalergan; N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine; Anhistabs; Pyranisamine; N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine; pyrilamine; Mepyramine(R); Histapyran; Mepyramine; Mepiramine; Antallergan; Dorantamin

物化性质

• 密度: 1.0141 (rough estimate)
• 沸点: 201ºC at 5 MM HG
• 分子式: C₁₇H₂₃N₃O
• 分子量: 285.38400
• 精确质量: 285.18400
• PSA: 28.60000
• LogP: 2.65840
• 折射率: nD25 1.5760-1.5765
• 储存条件: -20°C， 密封， 干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UT0875000 CHEMICAL NAME : Pyridine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)- CAS REGISTRY NUMBER : 91-84-9 BEILSTEIN REFERENCE NO. : 0269019 LAST UPDATED : 199701 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C17-H23-N3-O MOLECULAR WEIGHT : 285.43 WISWESSER LINE NOTATION : T6NJ DN1R DO1&2N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : OPHTAD Ophtalmologica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.96- 1978- Volume(issue)/page/year: 143,154,1962 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human DOSE/DURATION : 714 ug/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity REFERENCE : JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY. Volume(issue)/page/year: 19,313,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 950 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 160,4,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,1203,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 107 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,1203,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,131,1957 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 350 mg/kg SEX/DURATION : female 10-16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1878- Volume(issue)/page/year: 164,138,1962 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 50 mg/kg SEX/DURATION : female 5 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - stillbirth REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974

合成路线

2746-25-0 ~% 91-84-9

文献：Journal of the American Chemical Society, , vol. 68, p. 1999,2000 DE880749 , ; DRP/DRBP Org.Chem. US2502151 , ;

824-94-2 ~% 91-84-9

文献：Journal of the American Chemical Society, , vol. 68, p. 1999,2000 DE880749 , ; DRP/DRBP Org.Chem. US2502151 , ;

107-99-3 ~% 91-84-9

文献：Journal of the American Chemical Society, , vol. 68, p. 1999,2000 DE880749 , ; DRP/DRBP Org.Chem. US2502151 , ;

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