149934-19-0

• 常用中文名：9-Animominocycline
• 常用英文名：9-Animominocycline
• CAS号：149934-19-0
• 分子式：C₂₃H₂₈N₄O₇
• 分子量：472.491
• 发布时间：2016-08-28 18:08:48
• 更新时间：2024-01-05 11:07:50

名称

• 英文名: (4S,4aS,5aR,12aS)-9-Amino-4,7-bis(dimethylamino)-3,10,12,12a-tetr ahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecar boxamide
• 英文别名: 9-Aminominocycline; (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-((methoxymethylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide monohydrochloride; Sarecycline Hydrochloride; Sarecycline Hydrochloride [USAN]; (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide mono hydrochloride; 9-aminotetracycline; (4S,4aS,5aR,12aS)-9-Amino-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide; 9-amino-minocycline; (4S,4aS,5aR,12S)-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxanaphthacene-2-carboxamide; 2-Naphthacenecarboxamide, 9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-; (4S,4aS,5aR,12aS)-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-((methoxymethylamino)methyl)-1,11-dioxo-,hydrochloride (1:1),(4S,4aS,5aR,12aS)

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 830.7±65.0 °C at 760 mmHg
• 分子式: C₂₃H₂₈N₄O₇
• 分子量: 472.491
• 闪点: 456.2±34.3 °C
• 精确质量: 472.195801
• PSA: 191.64000
• LogP: -1.69
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.737

合成路线

149934-17-8 ~% 149934-19-0

文献：WYETH LLC; YANG, ChunHua; DILLON, John Leo Jr.; NAIK, Ramachandra Patent: WO2010/114680 A1, 2010 ; Location in patent: Page/Page column 27-28 ;

10118-90-8 ~% 149934-19-0

文献：Sum, Phaik-Eng; Ross, Adma T.; Petersen, Peter J.; Testa, Raymond T. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 400 - 403