Synthesis and antibacterial activity of 9-substituted minocycline derivatives

PE Sum, AT Ross, PJ Petersen, RT Testa

文献索引：Sum, Phaik-Eng; Ross, Adma T.; Petersen, Peter J.; Testa, Raymond T. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 400 - 403

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被引用次数: 29

摘要

A number of 9-acylamino and 9-sulfonylamino derivatives of minocycline have been synthesized for structure–activity relationship studies. These compounds showed activity against both tetracycline-susceptible and tetracycline-resistant strains. Many of the 9- sulfonylamino derivatives exhibited improved antibacterial activity against a number of tetracycline-and minocycline-resistant Gram-positive pathogens.