121-75-5

121-75-5结构式

常用中文名：马拉硫磷
常用英文名：Malathion
CAS号：121-75-5
分子式：C₁₀H₁₉O₆PS₂
分子量：330.358
相关类别：原料药其它化学药卫生防疫用药
发布时间：2018-03-21 08:00:00
更新时间：2024-01-06 05:53:05
Malathion是一种有机磷酸酯的副交感神经药物,不可逆地与胆碱酯酶结合,是一种杀虫剂,具有相对较低的人体毒性。

中文名	马拉硫磷
英文名	malathion
中文别名	马拉松防虫磷粮泰安 O,O-二甲基-S-[1,2-二(乙氧基羰基)乙基]二硫代磷酸酯粮虫净
英文别名	Malaphos rac-diethyl (2R)-2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate MFCD00036233 diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate flair Butanedioic acid, 2-[(dimethoxyphosphinothioyl)thio]-, diethyl ester maldison Butanedioic acid, [(dimethoxyphosphinothioyl)thio]-, diethyl ester diethyl (dimethoxyphosphinothioylthio)succinate Diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]succinate O,O-Dimethyl dithiophosphate of diethyl mercaptosuccinate Etiol SF 60 8059HC Diethyl 2-(dimethoxyphosphinothioylthio)succinate mercaptothion Diethyl-2-[(dimethoxyphosphorothioyl)sulfanyl]butandioat Organoderm EINECS 204-497-7 carbophos Malathion S-1,2-bis(ethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate S-Ester with O,O-Dimethyl Phosphorothioate Malation Derbac-M O,O-Dimethyl S-(1,2-dicarbethoxyethyl) phosphorodithioate American Cyanamid 4049 diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate Suleo-M diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate Fog 3

描述	Malathion是一种有机磷酸酯的副交感神经药物,不可逆地与胆碱酯酶结合,是一种杀虫剂,具有相对较低的人体毒性。
相关类别	信号通路 >> 神经信号通路 >> 疼痛研究领域 >> 神经疾病

密度	1.3±0.1 g/cm3
沸点	385.1±52.0 °C at 760 mmHg
熔点	2.85°C
分子式	C₁₀H₁₉O₆PS₂
分子量	330.358
闪点	186.7±30.7 °C
精确质量	330.036072
PSA	138.26000
LogP	2.92
外观性状	深棕色至黄色液体
蒸汽压	0.0±0.9 mmHg at 25°C
折射率	1.509
储存条件	储存注意事项储存于阴凉、通风良好的专用库房内，实行“双人收发，双人保管”制度。远离火种、热源。保持容器密封。应与氧化剂、碱类分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。
稳定性	1.稳定性稳定 2.禁配物强氧化剂、碱类 3.避免接触的条件受热 4.聚合危害不聚合 5.分解产物氧化磷、氧化硫
水溶解性	0.0145 g/100 mL
分子结构	1、摩尔折射率：77.50 2、摩尔体积（cm³/mol）：259.6 3、等张比容（90.2K）：680.4 4、表面张力（dyne/cm）：47.1 5、极化率：30.72
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:8 4.可旋转化学键数量:11 5.互变异构体数量:无 6.拓扑分子极性表面积128 7.重原子数量:19 8.表面电荷:0 9.复杂度:341 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:1 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：无色至淡黄色油状液体，有蒜恶臭，工业品带深褐色。 2.熔点（℃）：2.9~3.0 3.沸点（℃）：156~157（0.09kPa） 4.相对密度（水=1）：1.23（25℃） 5.饱和蒸气压（kPa）：1.43（156℃）^[] 6.辛醇/水分配系数：2.36 7.闪点（℃）：＞162（OC）；163（CC） 8.溶解性：微溶于水，易溶于醇、醚、酮等多数有机溶剂。

国标编号:	61875
ＣＡＳ:	121-75-5
中文名称:	马拉硫磷
英文名称:	malathion
别名:	马拉松；四O四九；马拉塞昂；O，O-二甲基-S-{1, 2-双(乙氧羰基)乙基}二硫代磷酸酯
分子式:	C₁₀H₁₉O₆PS₂
分子量:	330.36
熔点:	2.85℃ 沸点：156～15
密度:	相对密度(水=1)1.23
蒸汽压:	30℃
溶解性:	微溶于水，易溶于醇、酮、醚等
稳定性:	对光稳定但对热的稳定性稍差。在pH小于5或碱性溶液中?
外观与性状:	纯品为黄色油状液体，略带有醋气味
危险标记:	15(有害品，远离食品)
用途:	为非内吸性杀虫、杀螨剂。适用于防治水稻、高梁、蔬菜、果树等作物上的多种咀嚼式口器和刺吸式口器的害虫

2.对环境的影响:

一、健康危害

侵入途径：吸入、食入、经皮吸收。健康危害：抑制胆碱酯酶活性，造成神经生理功能紊乱。急性中毒：职业中毒不多见，多系口服引起。表现有头痛、头昏、食欲减退、恶心、呕吐、腹痛、腹泻、流涎、瞳孔缩小、呼吸道分泌物增多、多汗、肌束震颤等。重者出现肺水肿、脑水肿、昏迷、呼吸麻痹。部分病例可有心、肝、肾损害。少数严重病例在意识恢复后数周或数朋发生周围神经病。个别严重病例可发生迟发性猝死。血胆碱酯酶活性降低。慢性中毒：尚有争论。有神经衰弱综合征、多汗、肌束震颤等。血胆碱酯酶活性降低。对皮肤有刺激和致敏作用，可引起皮炎。

二、毒理学资料及环境行为

毒性：属低毒类。急性毒性：LD501800mg/kg(大鼠经口)；4444mg/kg(大鼠经皮) 亚急性和慢性毒性：慢性毒性很低，用含本品5000ppm饲料饲养大鼠2年，不出现死亡。致突变性：微生物致突变：鼠伤寒沙门氏菌10mg/L；枯草菌1nmol/皿；其它微生物100mg/L。姊妹染色单体交换：人类淋巴细胞20mg/L；人类成纤维细胞5mg/L。生殖毒性：大鼠经口最低中毒剂量(TDL0)：5550mg/kg(孕91天/1～20天)，致体壁发育异常。大鼠经口最低中毒剂量(TDL0)：283mg/kg(孕9天)，泌尿系统异常。以1000mg马拉硫磷原药/kg剂量的饮料喂大白鼠92周，体重能正常增加。水生生物忍度限量(48小时)：鲤鱼为9.0ppm 马拉硫磷对鱼类低毒，但其分解产物马来酸二乙酯，马来酸对水生生物高毒，对蜜蜂等益虫高毒。代谢和降解：马拉硫磷的降解主要通过水解和氧化作用。这些反应可以在空气、水、土壤和生物机体内进行。在土壤中马拉硫磷可因微生物活动而迅速水解。在消毒过的土壤中每天降解7%，而在普通土壤中97%马拉硫磷被降解。残留与蓄积：马拉硫磷属弱蓄积化合物，在土壤、作物和机体内的残留均不严重。迁移转化：马拉硫磷在环境中的行为与有机磷受农药的一般规律相同，可以在大气、水体和土壤间相互迁移，不大会由生物携带扩散。

危险特性：遇明火、高热可燃。与强氧化剂可发生反应。受热分解，放出磷、硫的氧化物等毒性气体。燃烧(分解)产物：一氧化碳、二氧化碳、氧化磷、氧化硫。

3.现场应急监测方法:

直接进水样气相色谱法

4.实验室监测方法:

气相色谱法(GB13192-91，水质)气相色谱法(GB/T5009.20-1996，粮食、蔬菜、油)酶-氯化铁比色法《空气中有害物质的测定方法》杭世平主编

5.环境标准:

中国(TJ36-79)	车间空气中有害物质最高容许浓度	2mg/m³
^{中国(GB11607-89)}	^{渔业水质标准}	^0.005mg/L
^{中国(GB3097-1997)}	^{海水水质标准}	^{0.0005～0.001mg/L}
^{中国(GHZB1-1999)}	^{地表水环境质量标准(I、II、III类水域)}	^0.005mg/L
^{中国(待颁布)}	^{饮用水源水中有害物质的最高容许浓度}	^0.25mg/L
^{中国(GB8978-1996)}	^{污水综合排放标准}	^{一级：不得检出} ^{二级：5.0mg/L} ^{三级：10mg/L}
联合国规划署(1974)	保护水生生物淡水中农药的最大允许浓度	0.008μg/L
^{中国(GB5127-85)}	^{食品中有机磷农药的允许标准}	^{3mg/kg(粮食)}

6.应急处理处置方法:

存放处要干燥、阴暗、密闭保管温度为1～30℃为宜。不能与酸、碱农药混合使用，不宜用金属器具盛装，以免分解、失效。

阿托品、解磷毒是马拉硫磷的急救药剂。误服本品按下述办法处置：1、请医生诊视；2、皮下注射1～2mg阿托品；3、充分洗胃；4、上部呼吸道受到刺激时可饮小量热牛奶及苏打；5、眼睛受到沾染时立即用洁净开水充分洗眼；6、皮肤发炎时可用功0%苏条水湿绷带包敷。

消防：可用水、砂土与泡沫灭火器进行灭火，灭火时应注意防止人身中毒。

泄漏应急处理：迅速撤离泄漏污染区人员至安全区，并进行隔离、严格限制出入。切断火源。建议应急人员穿防毒服等。小量泄漏：用砂土或其它不燃材料吸附或吸收。也可用大量水冲洗，洗水稀释后放入废水系统。大量泄漏构筑围堤或挖坑收容。用泡沫覆盖，降低蒸气灾害。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。

毒理学数据:

1.急性毒性

LD50：1800mg/kg（大鼠经口）

LC50：84.6mg/m³（大鼠吸入，4h）

2.刺激性暂无资料

3.亚急性与慢性毒性慢性毒性很低，用含本品5000ppm饲料饲养大鼠2a，不出现死亡。

4.致突变性微生物致突变：鼠伤寒沙门菌10mg/L；枯草菌1nmol/皿；其他微生物100mg/L。姐妹染色单体交换：人类淋巴细胞20mg/L；人类成纤维细胞5mg/L。

5.致畸性大鼠交配前91d到孕后1~20d，经口给予最低中毒剂量（TDLo）5550mg/kg，致体壁发育畸形。大鼠孕后9d经口给予最低中毒剂量（TDLo）283mg/kg，致泌尿生殖系统发育畸形。

6.致癌性 IARC致癌性评论：组3，现有的证据不能对人类致癌性进行分类。

7.其他大鼠经口最低中毒剂量（TDLo）：5550mg/kg（孕91d/1~20d），致体壁发育异常。大鼠经口最低中毒剂量（TDLo）：283mg/kg（孕9d），泌尿生殖系统异常。

生态学数据:

1.生态毒性

LC50：0.027~3.2mg/L（96h）（鱼）

EC50：0.0018mg/L（48h）（水蚤）

2.生物降解性

好氧生物降解（h）：100~1236

厌氧生物降解（h）：400~4944

3.非生物降解性

水相光解半衰期（h）：990~20000

空气中光氧化半衰期（h）：1~9.8

一级水解半衰期（h）：0.00077

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM8400000

CHEMICAL NAME :: Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorodithioate

CAS REGISTRY NUMBER :: 121-75-5

BEILSTEIN REFERENCE NO. :: 1804525

LAST UPDATED :: 199712

DATA ITEMS CITED :: 131

MOLECULAR FORMULA :: C10-H19-O6-P-S2

MOLECULAR WEIGHT :: 330.38

WISWESSER LINE NOTATION :: 2OV1YVO2&SPS&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 200 uL/kg

TOXIC EFFECTS :: Behavioral - coma Gastrointestinal - changes in structure or function of endocrine pancreas Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 471 mg/kg

TOXIC EFFECTS :: Behavioral - coma Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - chronic pulmonary edema Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 300 uL/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 43790 ug/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4444 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - muscle contraction or spasticity Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 193 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 221 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - reactivates cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 184 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1857 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 10 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraarterial

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1820 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - muscle contraction or spasticity Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 6700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 271 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - muscle contraction or spasticity Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 1485 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2250 mg/kg/45D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1050 mg/kg/21D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3358 mg/kg/14D-C

TOXIC EFFECTS :: Behavioral - fluid intake Blood - change in clotting factors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2300 ug/m3/4H/13W-I

TOXIC EFFECTS :: Endocrine - other changes Blood - changes in other cell count (unspecified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1050 mg/kg/7D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Behavioral - somnolence (general depressed activity) Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16800 mg/kg/24W-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 210 mg/kg/12W-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 175 mg/kg/4W-C

TOXIC EFFECTS :: Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 11760 mg/kg/24W-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 18900 mg/kg/24W-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5550 mg/kg

SEX/DURATION :: female 91 day(s) pre-mating female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - body wall

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 43920 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 191 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 283 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 80 mg/kg

SEX/DURATION :: male 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 540 mg/kg

SEX/DURATION :: female 28-30 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Dominant lethal test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

REFERENCE :: CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 57,280,1988 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,103,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,103,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 10 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,148,1971 OSHA PEL (Gen Indu):8H TWA 15 mg/m3 (skin), total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 15 mg/m3 (skin), total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 15 mg/m3 (skin), total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 15 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 10 mg/m3;Skin JAN 1993 OEL-AUSTRALIA:TWA 10 mg/m3;Skin JAN 1993 OEL-AUSTRIA:TWA 15 mg/m3 JAN 1993 OEL-BELGIUM:TWA 10 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 5 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993 OEL-FRANCE:TWA 10 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 15 mg/m3 JAN 1993 OEL-JAPAN:TWA 10 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 15 mg/m3;Skin JAN 1993 OEL-POLAND:TWA 15 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 10 mg/m3;Skin JAN 1993 OEL-THAILAND:TWA 15 mg/m3 JAN 1993 OEL-TURKEY:TWA 15 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MALATHION-air:10H TWA 10 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80046 No. of Facilities: 1609 (estimated) No. of Industries: 13 No. of Occupations: 14 No. of Employees: 17242 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80046 No. of Facilities: 2146 (estimated) No. of Industries: 15 No. of Occupations: 18 No. of Employees: 19170 (estimated) No. of Female Employees: 1909 (estimated)

符号	GHS07, GHS09
信号词	Warning
危害声明	H302-H317-H410
警示性声明	P273-P280-P301 + P312 + P330-P333 + P313-P391-P501
个人防护装备	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲)	Xn:Harmful
风险声明 (欧洲)	R22;R50/53
安全声明 (欧洲)	S2-S24-S60-S61-S62
危险品运输编码	UN 2783
RTECS号	WM8400000
包装等级	III
危险类别	6.1(b)
海关编码	2930909061

756-80-9

141-05-9

121-75-5

文献：Zhurnal Obshchei Khimii, , vol. 23, p. 1352,1356;engl.Ausg.S.1417,1420 DE847897 , ; US2578652 , ; DRP/DRBP Org.Chem. Chem.Wd.ShanghaiChem.Abstr., , p. 390 Chem.Wd.ShanghaiChem.Abstr., , p. 24386

67-56-1

141-05-9

~20%

71133-15-8

121-75-5

详细

文献：US2007/10496 A1, ; Page/Page column 13 ;

756-80-9

623-91-6

121-75-5

67-56-1

141-05-9

121-75-5

文献：DE1009181 , ; Chem.Wd.ShanghaiChem.Abstr., , p. 390 Chem.Wd.ShanghaiChem.Abstr., , p. 24386 NoevenytermelesChem.Abstr., , vol. 4, p. 351,357 NoevenytermelesChem.Abstr., , p. 1521

上游产品 4
756-80-9 141-05-9 67-56-1 623-91-6
下游产品 10
26377-29-7 64-17-5 17013-01-3 7554-12-3
756-80-9 1190-28-9 3344-12-5 1634-78-2
71133-16-9 33779-98-5

由五硫化二磷和甲醇合成二甲基二硫代磷酸酯，然后与顺丁烯二酸二乙酯加成得到马拉硫磷。将顺丁烯二酸二乙酯（以100%计为380kg）投入1000L搪玻璃反应锅内搅拌，控制温度在45℃以下，投入350kg五硫化二磷。慢慢滴加甲醇，控制温度为48-55℃，约2h加完250kg甲醇。加毕，保持65-75℃反应8h。反应产生硫化氢和逸出甲醇蒸气，经冷凝器使甲醇回流，硫化氢则用碱液吸收。反这过程在负压下进行。反应完成后，冷却至40-50℃，静置分层使杂质沉淀。上层原油先后进行水洗、碱洗、水洗，然后在真空脱水锅进行脱水，在85℃以下（真空度93.3kPa）使原油中的水分蒸发1.5-2h，得马拉硫磷原油。原料消耗定额：顺酐430kg/t、五硫化二磷470kg/t、乙醇420kg/t、甲醇390kg/t。

海关编码	2930909061
中文概述	2930909061 马拉硫磷、苏硫磷、赛硫磷等〔包括丙虫磷、双硫磷、亚砜磷、异亚砜磷〕退税率:9.0% 监管条件:S(进出口农药登记证明)
申报要素	品名, 成分含量, 用途
监管条件	S.进出口农药登记证明
Summary	2930909061 o,o,o',o'-tetramethyl o,o'-(thiobis(4,1-phenylene)) diphosphorothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

121-75-5	3344-12-5
35884-76-5	1190-28-9
347841-48-9	55733-40-9
91485-13-1	1634-78-2
376348-65-1	88859-04-5