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15307-86-5生产厂家

15307-86-5价格

15307-86-5

15307-86-5结构式
15307-86-5结构式
  • 常用中文名:双氯芬酸
  • 常用英文名:Diclofenac
  • CAS号:15307-86-5
  • 分子式:C14H11Cl2NO2
  • 分子量:296.149
  • 相关类别: 原料药 解热镇痛药 非甾抗炎药
  • 发布时间:2018-08-25 21:53:19
  • 更新时间:2024-01-01 18:19:39
  • Diclofenac 是一种有效的,非选择性的抗炎剂,为 COX 的抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50 值分别为 4 nM,1.3 nM;Diclofenac 同时对绵羊 COX-1 和 COX-2 的 IC50 值分别为 5.1 μM,0.84 μM。

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中文名 双氯芬酸
英文名 diclofenac
中文别名 2-(2,6-二氯苯氨基)苯乙酸
英文别名 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-
2-(2-((2,6-dichlorophenyl)amino)phenyl)acetic acid
Acetic acid, (o-(2,6-dichloroanilino)phenyl)-
2-[[2,6-Dichlorophenyl]amino]benzeneacetic acid
MFCD00451393
2-((2,6-dichlorophenyl)amino)benzeneacetic acid
Diclofenac acid
2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetic acid
N-(2,6-Dichlorophenyl)-o-aminophenylacetic Acid
Zorvolex
EINECS 239-348-5
{2-[(2,6-Dichlorophenyl)amino]phenyl}acetic acid
[2-(2,6-dichloroanilino)phenyl]acetic acid
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-
Motifene
(o-(2,6-Dichloroanilino)phenyl)acetic Acid
描述 Diclofenac 是一种有效的,非选择性的抗炎剂,为 COX 的抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50 值分别为 4 nM,1.3 nM;Diclofenac 同时对绵羊 COX-1 和 COX-2 的 IC50 值分别为 5.1 μM,0.84 μM。
相关类别
靶点

Human COX-2:1.3 nM (IC50, in CHO cells)

Human COX-1:4 nM (IC50, in CHO cells)

Ovine COX-2:0.84 μM (IC50)

Ovine COX-1:5.1 μM (IC50)

体外研究 双氯芬酸是一种有效的COX抑制剂,CHO细胞中人COX-1和COX-2的IC50分别为4 nM和1.3 nM。双氯芬酸有效阻断UX37细胞微粒体中COX-1介导的前列腺素产生,IC50为7±3 nM [1]。双氯芬酸钠表现出对COX-1和COX-2酶的抑制作用,IC50分别为5.1和0.84μM[2]。
体内研究 双氯芬酸(3mg/kg,bid,5天)显着增加大鼠粪便51Cr排泄,并且在施用1mg/kg每天两次,持续4天后,在松鼠猴中也观察到这种效果[1]。双氯芬酸(10mg/kg)在小鼠中显示出抗炎活性[2]。双氯芬酸(10 mg/kg)可降低氧化低密度脂蛋白(Ox-LDL),但通过肌内注射大鼠对过氧化氢酶和谷胱甘肽过氧化物酶的动力学参数没有影响[3]。
动物实验 大鼠[1]雄性Sprague-Dawley大鼠(150±200g)口服给予双氯芬酸一次(急性给药)或每天两次,持续5天(慢性给药)。在第4天早晨剂量后1小时获得血浆样品,用于测量双氯芬酸浓度。在第5天给予最后一次剂量后,立即通过尾静脉向大鼠注射来自供体大鼠的0.5mL 51Cr标记的红细胞,其与51铬酸钠一起孵育。将大鼠单独置于代谢笼中,随意食物和水。收集粪便48小时,51Cr粪便排泄量计算为总注射剂量的百分比(每只动物20mCi)[1]。松鼠猴[1]松鼠猴(Saimiri sciureus; 0.8±1.4 kg)口服双氯芬酸,每日两次,持续1±5天。给予最后一剂后1小时,通过隐静脉注射51CrCl3的无菌盐水(1mL / kg,每只动物4±5mCi),并获得血浆样品用于测量双氯芬酸浓度。然后将猴子单独圈养在代谢笼中。收集粪便24小时,51Cr粪便排泄量计算为总注射剂量的百分比[1]。
参考文献

[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.

[2]. Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.

[3]. Curcelli EC, et al. Beneficial effects of diclofenac therapy on serum lipids, oxidized low-density lipoprotein and antioxidant defenses in rats. Life Sci. 2008 Apr 9;82(15-16):892-8.

密度 1.4±0.1 g/cm3
沸点 412.0±45.0 °C at 760 mmHg
熔点 156-158ºC
分子式 C14H11Cl2NO2
分子量 296.149
闪点 203.0±28.7 °C
精确质量 295.016693
PSA 49.33000
LogP 4.06
外观性状 白色至淡黄色结晶粉末
蒸汽压 0.0±1.0 mmHg at 25°C
折射率 1.662
储存条件 室温,干燥
水溶解性 可溶于:甲醇
2-(2,6-Dichloroanilino)phenylacetic Acid Revision number: 5
SAFETY DATA SHEET

Section1. IDENTIFICATION
Product name:2-(2,6-Dichloroanilino)phenylacetic Acid

Revision number:5

Section2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDSNot classified
HEALTH HAZARDS
Acute toxicity (Oral)Category 3
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal wordDanger
Hazard statementsToxic if swallowed
Precautionary statements:
[Prevention]Do not eat, drink or smoke when using this product.
Wash hands thoroughly after handling.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Rinse
[Response]
mouth.
Store locked up.
[Storage]
[Disposal]Dispose of contents/container through a waste management company authorized by
the local government.

Section3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture:Substance
Components:2-(2,6-Dichloroanilino)phenylacetic Acid
Percent:>98.0%(GC)(T)
CAS Number:15307-86-5
Synonyms:Diclofenac
Chemical Formula:C14H11Cl2NO2

Section4. FIRST AID MEASURES
Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact:Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
2-(2,6-Dichloroanilino)phenylacetic Acid

Section4. FIRST AID MEASURES
Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion:Immediately call a POISON CENTER or doctor/physician. Rinse mouth.
Protection of first-aiders:A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

Section5. FIRE-FIGHTING MEASURES
Dry chemical, foam, water spray, carbon dioxide.
Suitable extinguishing
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical:generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

Section6. ACCIDENTAL RELEASE MEASURES
Personal precautions,Use extra personal protective equipment (P3 filter respirator for toxic particles). Keep
protective equipment and people away from and upwind of spill/leak. Entry to non-involved personnel should
emergency procedures: be controlled around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

Section7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures:Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a closed system if possible. Use a local exhaust if dust or aerosol will be
generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions:Keep container tightly closed. Store in a cool and dark place.
Store locked up.
Store away from incompatible materials such as oxidizing agents.
Packaging material:Comply with laws.

Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls:Install a closed system or local exhaust. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator, self-contained breathing apparatus(SCBA), supplied air respirator,
etc. Use respirators approved under appropriate government standards and follow
local and national regulations.
Impervious gloves.
Hand protection:
Eye protection:Safety goggles. A face-shield, if the situation requires.
Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.

Section9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C):Solid
Form:Crystal- Powder
White - Very pale yellow
Colour:
2-(2,6-Dichloroanilino)phenylacetic Acid

Section9. PHYSICAL AND CHEMICAL PROPERTIES
Odour:No data available
pH: No data available
Melting point/freezing point:158°C (dec.)
Boiling point/range:No data available
Flash point:No data available
Flammability or explosive
limits:
Lower:No data available
Upper:No data available
Relative density:No data available
Solubility(ies):
[Water]No data available
[Other solvents]
Soluble:Methanol
Log Pow:3.03

Section10. STABILITY AND REACTIVITY
Chemical stability:Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Hydrogen chloride
products:

Section11. TOXICOLOGICAL INFORMATION
Acute Toxicity:orl-rat LD50:62500 ug/kg
ipr-mus LD50:345 mg/kg
Skin corrosion/irritation: No data available
Serious eyeNo data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC =No data available
NTP =No data available
Reproductive toxicity:No data available
RTECS Number:AG6310000

Section12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
Crustacea:No data available
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobility in soil
Log Pow:3.03
No data available
Soil adsorption (Koc):
Henry's LawNo data available
constant(PaM3/mol):

Section13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.
2-(2,6-Dichloroanilino)phenylacetic Acid

Section14. TRANSPORT INFORMATION
Hazards Class:6.1: Toxic substance.
UN-No:2811
Proper shipping name:Toxic solid, organic, n.o.s.
Packing group:III

Section15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.


SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AG6310000
CHEMICAL NAME :
Acetic acid, (o-(2,6-dichloroanilino)phenyl)-
CAS REGISTRY NUMBER :
15307-86-5
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C14-H11-Cl2-N-O2
MOLECULAR WEIGHT :
296.16
WISWESSER LINE NOTATION :
QV1R BMR BG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
1070 ug/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 117,1058,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
62500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1398,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 37,148,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
345 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 43,44,1993 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
JCGBDF Journal of Craniofacial Genetics and Developmental Biology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 10,83,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
4 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
JCGBDF Journal of Craniofacial Genetics and Developmental Biology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 10,83,1990

危害码 (欧洲) Xi
危险品运输编码 3249
包装等级 III
危险类别 6.1(b)
海关编码 2942000000
海关编码 2922499990
中文概述 2922499990 其他氨基酸及其酯及它们的盐(含有一种以上含氧基的除外). 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件 A.入境货物通关单 B.出境货物通关单
检验检疫 P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%