2825-00-5

• 常用中文名：Aureothin
• 常用英文名：Aureothin
• CAS号：2825-00-5
• 分子式：C₂₂H₂₃NO₆
• 分子量：397.42100
• 相关类别： 信号通路 抗感染 HIV
• 发布时间：2017-05-23 15:23:13
• 更新时间：2024-01-02 10:42:51
• Aureothin是一种天然聚酮,是一种HIV抑制剂,其50为5.3 nM。金黄色素是一种微生物杀生物剂[1][2]。

名称

• 英文名: 2-Methoxy-3,5-dimethyl-6-{(4Z)-4-[(2E)-2-methyl-3-(4-nitrophenyl) -2-propen-1-ylidene]tetrahydro-2-furanyl}-4H-pyran-4-one

物化性质

• 密度: 1.26g/cm3
• 沸点: 591.4ºC at 760mmHg
• 分子式: C₂₂H₂₃NO₆
• 分子量: 397.42100
• 闪点: 235ºC
• 精确质量: 397.15300
• PSA: 94.49000
• LogP: 5.18790
• 蒸汽压: 5.86E-14mmHg at 25°C
• 折射率: 1.593

生物活性

• 描述: Aureothin是一种天然聚酮,是一种HIV抑制剂,其50为5.3 nM。金黄色素是一种微生物杀生物剂[1][2]。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 靶点:

  HIV:5.3 nM (IC50)

• 体外研究: 奥雷辛显示出对埃及伊蚊的杀幼虫活性,处理后 24小时的 LC50型值为 1.5 ppm处理后 48小时的 LC50型值为 3.8 ppm[1]
• 参考文献:

  [1]. Seong Jong Kim, et al. Streptomyces distallicus, a Potential Microbial Biolarvicide. J Agric Food Chem. 2022 Sep 14;70(36):11274-11280.

  [2]. Alexander Herrmann, et al. Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin. Sci Rep. 2020 Jan 28;10(1):1326.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UQ0800000 CHEMICAL NAME : 4H-Pyran-4-one, 3,5-dimethyl-, 2-methoxy-6-(tetrahydro-4-(beta-methyl-p-nitrocinnamy lidene)- 2-furyl)- CAS REGISTRY NUMBER : 2825-00-5 BEILSTEIN REFERENCE NO. : 0058476 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C22-H23-N-O6 MOLECULAR WEIGHT : 397.46 WISWESSER LINE NOTATION : T6O DVJ BO1 C1 E1 F- ET5O CYTJ CU1Y1&U1R DNW HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 33,1790,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 740 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 33,1790,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 7,60,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1260 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02084