2825-00-5

2825-00-5 structure

Name: Aureothin
Chemical Name: 2-Methoxy-3,5-dimethyl-6-{(4Z)-4-[(2E)-2-methyl-3-(4-nitrophenyl) -2-propen-1-ylidene]tetrahydro-2-furanyl}-4H-pyran-4-one
CAS Number: 2825-00-5
Molecular Formula: C₂₂H₂₃NO₆
Molecular Weight: 397.42100
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2017-05-23 15:23:13
Modify Date: 2024-01-02 10:42:51
Aureothin, is a natural polyketide, is a HIV inhibitor with an 50 of 5.3 nM. Aureothin is a microbial biolarvicide[1][2].

Name	2-Methoxy-3,5-dimethyl-6-{(4Z)-4-[(2E)-2-methyl-3-(4-nitrophenyl) -2-propen-1-ylidene]tetrahydro-2-furanyl}-4H-pyran-4-one

Description	Aureothin, is a natural polyketide, is a HIV inhibitor with an 50 of 5.3 nM. Aureothin is a microbial biolarvicide[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV:5.3 nM (IC50)
In Vitro	Aurethin 显示出对埃及伊蚊的杀幼虫活性，处理后 24 小时的 LC50 值为 1.5 ppm，处理后 48 小时的 LC50 值为 3.8 ppm[1]。
References	[1]. Seong Jong Kim, et al. Streptomyces distallicus, a Potential Microbial Biolarvicide. J Agric Food Chem. 2022 Sep 14;70(36):11274-11280. [2]. Alexander Herrmann, et al. Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin. Sci Rep. 2020 Jan 28;10(1):1326.

CHEMICAL NAME :: 4H-Pyran-4-one, 3,5-dimethyl-, 2-methoxy-6-(tetrahydro-4-(beta-methyl-p-nitrocinnamy lidene)- 2-furyl)-

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 33,1790,1969

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 33,1790,1969

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 7,60,1954

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02084