62288-83-9

• 常用中文名：1-去氨基-8-右旋精氨酸加压素
• 常用英文名：Desmopressin Acetate
• CAS号：62288-83-9
• 分子式：C₄₈H₆₈N₁₄O₁₄S₂
• 分子量：1129.269
• 相关类别： 原料药 泌尿系统用药 尿崩症用药
• 发布时间：2018-11-28 10:16:11
• 更新时间：2024-01-02 14:16:39
• Desmopressin(DDAVP)醋酸盐是抗利尿激素精氨酸加压素类似物。

名称

• 中文名: 1-去氨基-8-右旋精氨酸加压素
• 英文名: desmopressin
• 中文别名: 醋酸去氨加压素
• 英文别名: Glycinamide, 1-[[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-L-prolyl-L-arginyl-, acetate (1:1) (salt); 1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide acetate (salt); 1-{[(4R,7S,10S,13S,16S)-7-(2-Amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide acetate (1:1); acide acétique - (2S)-1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoéthyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-N-{(1S)-1-[(2-amino-2-oxoéthyl)carbamoyl]-4-carbamimidamidobutyl}pyrrolidine-2-carboxamide (1:1); (2S)-1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-N-{(1S)-1-[(2-amino-2-oxoethyl)carbamoyl]-4-carbamimidamidobutyl}pyrrolidine-2-carboxamide acetate (salt); (2S)-1-{[(4R,7S,10S,13S,16S)-7-(2-Amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-N-{(1S)-1-[(2-amino-2-oxoethyl)carbamoyl]-4-carbamimidamidobutyl}pyrrolidin-2-carboxamidacetat(salt); Desmopressin (Acetate)

物化性质

• 密度: 1.56 g/cm3
• 沸点: 1667.7ºC at 760 mmHg
• 熔点: 170-172ºC
• 分子式: C₄₈H₆₈N₁₄O₁₄S₂
• 分子量: 1129.269
• 闪点: 962.4ºC
• 精确质量: 1128.448120
• PSA: 523.31000
• LogP: 1.61440
• 储存条件: -20?C Freezer

生物活性

• 描述: Desmopressin(DDAVP)醋酸盐是抗利尿激素精氨酸加压素类似物。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Vande Walle J, Stockner M, Raes A, N?rgaard JP. Desmopressin 30 years in clinical use: a safety review. Curr Drug Saf. 2007 Sep;2(3):232-8.

  [2]. Franchini M, Zaffanello M, Lippi G. The use of desmopressin in mild hemophilia A. Blood Coagul Fibrinolysis. 2010 Oct;21(7):615-9.

  [3]. Sánchez-Luceros A, Meschengieser SS, Woods AI et al. Biological and clinical response to desmopressin (DDAVP) in a retrospective cohort study of children with low von Willebrand factor levels and bleeding history. Thromb Haemost. 2010 Nov;104(5):984-9.

  [4]. Alonso DF, Ripoll GV, Garona J et al. Metastasis: recent discoveries and novel perioperative treatment strategies with particular interest in the hemostatic compound desmopressin. Curr Pharm Biotechnol. 2011 Nov;12(11):1974-80.

  [5]. Tsukamoto I. Recent patenting activities in the discovery and development of vasopressin V2 receptor agonists. Expert Opin Ther Pat. 2012 Jun;22(6):579-86.

  [6]. Desmopressin

安全

• 危害码 (欧洲): Xn
• 安全声明 (欧洲): S36