309-29-5

• 常用中文名：多沙普仑
• 常用英文名：Doxapram
• CAS号：309-29-5
• 分子式：C₂₄H₃₀N₂O₂
• 分子量：378.507
• 相关类别： 原料药 神经系统用药 中枢兴奋药
• 发布时间：2018-06-29 10:37:06
• 更新时间：2024-01-08 19:07:51
• Doxapram能抑制TASK-1,TASK-3和TASK-1/TASK-3异二聚体通道,EC50分别为410 nM,37 μM和9 μM。

名称

• 中文名: 多沙普仑
• 英文名: doxapram
• 中文别名: 1-乙基-4-(2-吗啉-4-乙基)-3,3-二苯基-2-吡咯烷酮; 吗乙苯吡酮
• 英文别名: Doxapramum; Dopram; 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone; 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one; 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-; Doxapram HCL; doxapram; UNII:94F3830Q73; 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one; doxapram hydrochloride; 2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 536.4±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₀N₂O₂
• 分子量: 378.507
• 闪点: 278.2±30.1 °C
• 精确质量: 378.230713
• PSA: 32.78000
• LogP: 3.23
• 外观性状: 粉末
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.562
• 储存条件: -20℃

生物活性

• 描述: Doxapram能抑制TASK-1,TASK-3和TASK-1/TASK-3异二聚体通道,EC50分别为410 nM,37 μM和9 μM。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钾通道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Cotten JF, et al. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg, 2006, 102(3), 779-785.

  [2]. Peers, C., Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res, 1991. 568(1-2): p. 116-22.

  [3]. Anderson-Beck, R., et al., Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett, 1995. 187(1): p. 25-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UY5769500 CHEMICAL NAME : 2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl- CAS REGISTRY NUMBER : 309-29-5 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C24-H30-N2-O2 MOLECULAR WEIGHT : 378.56 WISWESSER LINE NOTATION : T6N DOTJ A2- DT5NVTJ A2 CR& CR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 268 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) REFERENCE : JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 30,522,1978 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 1800 ug/kg SEX/DURATION : female 16 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo REFERENCE : BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year: 84,48,1977

安全

• 海关编码: 2934999090

合成路线

113-07-5 ~% 309-29-5

文献：US2013/109689 A1, ; Paragraph 0084 ;

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%