863031-21-4

• 常用中文名：阿齐沙坦奥美沙坦酯
• 常用英文名：Azilsartan medoxomil
• CAS号：863031-21-4
• 分子式：C₃₀H₂₄N₄O₈
• 分子量：568.534
• 相关类别： 生物化工 抑制剂 内分泌及激素(Endocrinology & Hormones) RAAS 拮抗剂
• 发布时间：2018-08-16 01:17:56
• 更新时间：2026-06-30 16:58:36
• Azilsartan酯(TAK 491)是口服活性的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。

名称

• 中文名: 阿齐沙坦奥美沙坦酯
• 英文名: azilsartan medoxomil
• 中文别名: 阿齐沙坦酯,10 MM DMSO 溶液; 1-[[2-(2,5-二氢-5-氧代-1,2,4-恶二唑-3-基)[1,1-联苯]-4-基]甲基]-2-乙氧基-1H-苯并咪唑-7-羧酸 (5-甲基-2-氧代-1,3-二恶茂-4-基)酯; 美阿沙坦钾中间体AMP4(1-[[2'-(5-氧代-2,5-二氢-1,2,4-噁二唑-3-基)[1,1'-联苯]-4-基]甲基]-2-乙氧基-1H-苯并咪唑-7-羧酸 (5-甲基-2-氧代-1,3-二恶茂-4-基)甲酯); 美阿沙坦; 阿齐沙坦-麦多罗米; 1-[[2'-(2,5-二氢-5-氧代-1,2,4-恶二唑-3-基)[1,1'-联苯]-4-基]甲基]-2-乙氧基-1H-苯并咪唑-7-羧酸 (5-甲基-2-氧代-1,3-二恶茂-4-基)甲酯; 阿齐沙坦酯; 阿齐沙坦酯钾盐中间体; 阿齐沙坦酯 晶型I; 阿齐沙坦酯 1-[[2'-(2,5-二氢-5-氧代-1,2,4-恶二唑-3-基)[1,1'-联苯]-4-基]甲基]-2-乙氧基-1H-苯并咪唑-7-羧酸 (5-甲基-2-氧代-1,3-二恶茂-4-基)甲酯; 阿奇沙坦酯
• 英文别名: Azilsartan kamedoxomil; (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate; (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate; 1H-BenziMidazole-7-cboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-, (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester; TAK 491; 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzim; azilstan medoxomil 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-cboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester; (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate; (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-+oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-cboxylate; Azilsan medoxomil; Azilstan MedoxiMil; (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylate; (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester of 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid; Azilstan Kamedoxomil Form I; (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate; Edarbi; 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-cboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester; Azilstan Acid Medoxomil Ester; Azilstan Medoxomil, 10 mM in DMSO; Azilstan medoxomil; Azilstan medoxomilQ: What is Azilstan medoxomil Q: What is the CAS Number of Azilstan medoxomil Q: What is the storage condition of Azilstan medoxomil Q: What e the applications of Azilstan medoxomil; azilsartanum medoxomilum; Azilsartan; Meastan potassium Impurity 36; UNII-LL0G25K7I2; Aziztan ester; Azilsartan (medoxomil); (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl 2-ethoxy-1-([2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]Methyl)-1H-benziMidazole-7-cboxylate; 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester; [14C]-Azilsartan medoxomil; Azilstan Medoxomil //BP

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 748.0±70.0 °C at 760 mmHg
• 分子式: C₃₀H₂₄N₄O₈
• 分子量: 568.534
• 闪点: 406.2±35.7 °C
• 精确质量: 568.159424
• PSA: 155.59000
• LogP: 5.73
• 外观性状: 白色至米色粉末
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.680
• 储存条件: -20℃

生物活性

• 描述: Azilsartan酯(TAK 491)是口服活性的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Kajiya T, Ho C, Wang J, Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J Hypertens. 2011 Dec;29(12):2476-83.

  [2]. Kusumoto K, Igata H, Ojima M, Antihypertensive, insulin-sensitising and renoprotective effects of a novel, potent and long-acting angiotensin II type 1 receptor blocker, azilsartan medoxomil, in rat and dog models.

  [3]. Perry CM. Azilsartan medoxomil: a review of its use in hypertension. Clin Drug Investig. 2012 Sep 1;32(9):621-39.

  [4]. Pierini D, Anderson KV. Azilsartan medoxomil/chlorthalidone: a new fixed-dose combination antihypertensive. Ann Pharmacother. 2013 May;47(5):694-703.

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