449811-01-2

• 常用中文名：Pamapimod
• 常用英文名：Pamapimod
• CAS号：449811-01-2
• 分子式：C₁₉H₂₀F₂N₄O₄
• 分子量：406.38300
• 相关类别： 信号通路 MAPK/ERK信号通路 p38 MAPK
• 发布时间：2016-10-26 16:16:45
• 更新时间：2025-08-27 10:12:17
• Pamapimod是一种有效的p38增殖蛋白激酶抑制剂。Pamapimod可以抑制p38α和p38β的酶活性,IC50值分别为0.014±0.002和0.48±0.04μM。Pamapimod 也能以IC50为0.06μm的效果抑制THP-1细胞的p38活性。

名称

• 中文名: Pamapimod
• 英文名: 6-(2,4-difluorophenoxy)-2-(1,5-dihydroxypentan-3-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one
• 英文别名: Pamapimod; R-1503

物化性质

• 分子式: C₁₉H₂₀F₂N₄O₄
• 分子量: 406.38300
• 精确质量: 406.14500
• PSA: 112.73000
• LogP: 1.36620
• 外观性状: 粉末
• 储存条件: -20℃

生物活性

• 描述: Pamapimod是一种有效的p38增殖蛋白激酶抑制剂。Pamapimod可以抑制p38α和p38β的酶活性,IC50值分别为0.014±0.002和0.48±0.04μM。Pamapimod 也能以IC50为0.06μm的效果抑制THP-1细胞的p38活性。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 癌症
• 参考文献:

  [1]. Hill, R. J. et al. Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity. The Journal of pharmacology and experimental therapeutics 327, 610-619, doi:10.1124/jpet.108.139006 (2008).

合成路线

449808-50-8 1032451-78-7 ~91% 449811-01-2

文献：Goldstein, David M.; Soth, Michael; Gabriel, Tobias; Dewdney, Nolan; Kuglstatter, Andreas; Arzeno, Humberto; Chen, Jeffrey; Bingenheimer, William; Dalrymple, Stacie A.; Dunn, James; Farrell, Robert; Frauchiger, Sandra; La Fargue, Joann; Ghate, Manjiri; Graves, Bradford; Hill, Ronald J.; Li, Fujun; Litman, Renee; Loe, Brad; McIntosh, Joel; McWeeney, Daniel; Papp, Eva; Park, Jaehyeon; Reese, Harlan F.; Roberts, Richard T.; Rotstein, David; San Pablo, Bong; Sarma, Keshab; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca T.; Sjogren, Eric B.; Tan, Yunchou; Trejo, Alejandra; Welch, Mary; Weller, Paul; Wong, Brian R.; Zecic, Hasim Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2255 - 2265

449811-12-5 ~% 449811-01-2

文献：Goldstein, David M.; Soth, Michael; Gabriel, Tobias; Dewdney, Nolan; Kuglstatter, Andreas; Arzeno, Humberto; Chen, Jeffrey; Bingenheimer, William; Dalrymple, Stacie A.; Dunn, James; Farrell, Robert; Frauchiger, Sandra; La Fargue, Joann; Ghate, Manjiri; Graves, Bradford; Hill, Ronald J.; Li, Fujun; Litman, Renee; Loe, Brad; McIntosh, Joel; McWeeney, Daniel; Papp, Eva; Park, Jaehyeon; Reese, Harlan F.; Roberts, Richard T.; Rotstein, David; San Pablo, Bong; Sarma, Keshab; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca T.; Sjogren, Eric B.; Tan, Yunchou; Trejo, Alejandra; Welch, Mary; Weller, Paul; Wong, Brian R.; Zecic, Hasim Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2255 - 2265

17759-30-7 ~% 449811-01-2

文献：Goldstein, David M.; Soth, Michael; Gabriel, Tobias; Dewdney, Nolan; Kuglstatter, Andreas; Arzeno, Humberto; Chen, Jeffrey; Bingenheimer, William; Dalrymple, Stacie A.; Dunn, James; Farrell, Robert; Frauchiger, Sandra; La Fargue, Joann; Ghate, Manjiri; Graves, Bradford; Hill, Ronald J.; Li, Fujun; Litman, Renee; Loe, Brad; McIntosh, Joel; McWeeney, Daniel; Papp, Eva; Park, Jaehyeon; Reese, Harlan F.; Roberts, Richard T.; Rotstein, David; San Pablo, Bong; Sarma, Keshab; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca T.; Sjogren, Eric B.; Tan, Yunchou; Trejo, Alejandra; Welch, Mary; Weller, Paul; Wong, Brian R.; Zecic, Hasim Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2255 - 2265

5909-24-0 ~% 449811-01-2

文献：Goldstein, David M.; Soth, Michael; Gabriel, Tobias; Dewdney, Nolan; Kuglstatter, Andreas; Arzeno, Humberto; Chen, Jeffrey; Bingenheimer, William; Dalrymple, Stacie A.; Dunn, James; Farrell, Robert; Frauchiger, Sandra; La Fargue, Joann; Ghate, Manjiri; Graves, Bradford; Hill, Ronald J.; Li, Fujun; Litman, Renee; Loe, Brad; McIntosh, Joel; McWeeney, Daniel; Papp, Eva; Park, Jaehyeon; Reese, Harlan F.; Roberts, Richard T.; Rotstein, David; San Pablo, Bong; Sarma, Keshab; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca T.; Sjogren, Eric B.; Tan, Yunchou; Trejo, Alejandra; Welch, Mary; Weller, Paul; Wong, Brian R.; Zecic, Hasim Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2255 - 2265

1117-23-3 ~% 449811-01-2

文献：Goldstein, David M.; Soth, Michael; Gabriel, Tobias; Dewdney, Nolan; Kuglstatter, Andreas; Arzeno, Humberto; Chen, Jeffrey; Bingenheimer, William; Dalrymple, Stacie A.; Dunn, James; Farrell, Robert; Frauchiger, Sandra; La Fargue, Joann; Ghate, Manjiri; Graves, Bradford; Hill, Ronald J.; Li, Fujun; Litman, Renee; Loe, Brad; McIntosh, Joel; McWeeney, Daniel; Papp, Eva; Park, Jaehyeon; Reese, Harlan F.; Roberts, Richard T.; Rotstein, David; San Pablo, Bong; Sarma, Keshab; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca T.; Sjogren, Eric B.; Tan, Yunchou; Trejo, Alejandra; Welch, Mary; Weller, Paul; Wong, Brian R.; Zecic, Hasim Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2255 - 2265

77313-09-8 ~% 449811-01-2

文献：Goldstein, David M.; Soth, Michael; Gabriel, Tobias; Dewdney, Nolan; Kuglstatter, Andreas; Arzeno, Humberto; Chen, Jeffrey; Bingenheimer, William; Dalrymple, Stacie A.; Dunn, James; Farrell, Robert; Frauchiger, Sandra; La Fargue, Joann; Ghate, Manjiri; Graves, Bradford; Hill, Ronald J.; Li, Fujun; Litman, Renee; Loe, Brad; McIntosh, Joel; McWeeney, Daniel; Papp, Eva; Park, Jaehyeon; Reese, Harlan F.; Roberts, Richard T.; Rotstein, David; San Pablo, Bong; Sarma, Keshab; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca T.; Sjogren, Eric B.; Tan, Yunchou; Trejo, Alejandra; Welch, Mary; Weller, Paul; Wong, Brian R.; Zecic, Hasim Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2255 - 2265

76360-82-2 ~% 449811-01-2

文献：Goldstein, David M.; Soth, Michael; Gabriel, Tobias; Dewdney, Nolan; Kuglstatter, Andreas; Arzeno, Humberto; Chen, Jeffrey; Bingenheimer, William; Dalrymple, Stacie A.; Dunn, James; Farrell, Robert; Frauchiger, Sandra; La Fargue, Joann; Ghate, Manjiri; Graves, Bradford; Hill, Ronald J.; Li, Fujun; Litman, Renee; Loe, Brad; McIntosh, Joel; McWeeney, Daniel; Papp, Eva; Park, Jaehyeon; Reese, Harlan F.; Roberts, Richard T.; Rotstein, David; San Pablo, Bong; Sarma, Keshab; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca T.; Sjogren, Eric B.; Tan, Yunchou; Trejo, Alejandra; Welch, Mary; Weller, Paul; Wong, Brian R.; Zecic, Hasim Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2255 - 2265

185040-32-8 ~% 449811-01-2

文献：Goldstein, David M.; Soth, Michael; Gabriel, Tobias; Dewdney, Nolan; Kuglstatter, Andreas; Arzeno, Humberto; Chen, Jeffrey; Bingenheimer, William; Dalrymple, Stacie A.; Dunn, James; Farrell, Robert; Frauchiger, Sandra; La Fargue, Joann; Ghate, Manjiri; Graves, Bradford; Hill, Ronald J.; Li, Fujun; Litman, Renee; Loe, Brad; McIntosh, Joel; McWeeney, Daniel; Papp, Eva; Park, Jaehyeon; Reese, Harlan F.; Roberts, Richard T.; Rotstein, David; San Pablo, Bong; Sarma, Keshab; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca T.; Sjogren, Eric B.; Tan, Yunchou; Trejo, Alejandra; Welch, Mary; Weller, Paul; Wong, Brian R.; Zecic, Hasim Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2255 - 2265

上下游产品

上游产品  7
449811-12-5 17759-30-7 5909-24-0 1117-23-3
77313-09-8 76360-82-2 185040-32-8
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