14860-49-2

14860-49-2结构式
14860-49-2结构式
  • 常用中文名:氯丁替诺
  • 常用英文名:Clobutinol
  • CAS号:14860-49-2
  • 分子式:C14H22ClNO
  • 分子量:255.78400
  • 相关类别: 原料药 呼吸系统用药 镇咳药
  • 发布时间:2018-03-14 08:00:00
  • 更新时间:2024-01-08 09:41:35
  • 克洛布蒂诺是一种具有镇咳作用的化合物。克洛替诺影响心率和血压,可用于咳嗽相关研究[1][2][3]。

化源商城直购

中文名 氯苯胺丁醇
英文名 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol
英文别名 Clobutinol
Clobutinol HCl
EINECS 238-926-4
描述 克洛布蒂诺是一种具有镇咳作用的化合物。克洛替诺影响心率和血压,可用于咳嗽相关研究[1][2][3]。
相关类别
体外研究 克洛替诺(10μM)显著抑制hERG表达细胞中的电压门控外向电流[1]。克洛替诺(0-1000μM)抑制IC50值为1.9μM的hERG转染细胞的外向电流[1]。
体内研究 克洛替诺(1-20 mg/kg;静脉注射一次)对豚鼠的气道没有明显影响[2]。克洛替诺(1和10 mg/kg;静脉注射一次)影响豚鼠的心率和平均血压[3]。动物模型:麻醉豚鼠[2]剂量:1-20mg/kg给药:静脉注射;结果:对气道无明显影响,但高剂量对心血管系统有显著影响。动物模型:麻醉闭胸豚鼠[3]剂量:1和10 mg/kg给药:静脉注射;结果:1 mg/kg剂量可降低心率,10 mg/kg剂量可以降低心率和平均血压。
参考文献

[1]. Deisemann H, et al. Effects of common antitussive drugs on the hERG potassium channel current. J Cardiovasc Pharmacol. 2008 Dec;52(6):494-9.

[2]. Salonen RO. Comparison of the effects of two opioid antitussives, vadocaine hydrochloride, clobutinol and lidocaine on lung mechanics in guinea-pigs. Arzneimittelforschung. 1988 Apr;38(4A):609-12.

[3]. Takahara A, Set al. Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031. J Cardiovasc Pharmacol. 2009 Dec;54(6):552-9.

密度 1.0373 (rough estimate)
沸点 bp12 179-180°
分子式 C14H22ClNO
分子量 255.78400
精确质量 255.13900
PSA 23.47000
LogP 2.83120
折射率 1.6330 (estimate)
计算化学

1.疏水参数计算参考值(XlogP):3.2

2.氢键供体数量:1

3.氢键受体数量:2

4.可旋转化学键数量:5

5.互变异构体数量:无

6.拓扑分子极性表面积:23.5

7.重原子数量:17

8.表面电荷:0

9.复杂度:226

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:2

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SG7885000
CHEMICAL NAME :
Phenethyl alcohol, p-chloro-alpha-(2-(dimethylamino)-1-methylethyl)-alph a-methyl-
CAS REGISTRY NUMBER :
14860-49-2
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C14-H22-Cl-N-O
MOLECULAR WEIGHT :
255.82
WISWESSER LINE NOTATION :
GR D1XQ1&Y1&1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
802 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,119,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
165 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,119,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
775 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,119,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,119,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
334 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,119,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
128 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,119,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
262 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,1067,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
53 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,119,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
45300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,1067,1974

海关编码 2922199090
海关编码 2922199090
中文概述 2922199090. 其他氨基醇及其醚,酯和它们的盐(但含一种以上含氧基的除外). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%