2482-80-6

• 常用中文名：Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-
• 常用英文名：Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-
• CAS号：2482-80-6
• 分子式：C₈H₉ClN₄
• 分子量：196.63700
• 相关类别： 研究领域 癌症
• 发布时间：2017-03-07 08:33:40
• 更新时间：2025-11-24 16:27:27
• Ethimidine (Aethimidinum) 可以降低先前移植肉瘤或癌细胞的大鼠血清中的游离 SH (巯基)。

名称

• 英文名: 2,4-bis(aziridin-1-yl)-6-chloropyrimidine
• 英文别名: 2,4-Bis-aziridin-1-yl-6-chlor-pyrimidin; Ethymidine; Aethimidinum; 2,4-Diethylenimino-6-chloropyrimidine; 2,4-bis-aziridin-1-yl-6-chloro-pyrimidine; Etimidin; Ethimidine; 2,6-Diethylenimino-4-chloropyrimidine; Aethimidinium

物化性质

• 密度: 1.561g/cm3
• 沸点: 410.4ºC at 760mmHg
• 分子式: C₈H₉ClN₄
• 分子量: 196.63700
• 闪点: 202ºC
• 精确质量: 196.05200
• PSA: 31.80000
• LogP: 0.90000
• 蒸汽压: 6.06E-07mmHg at 25°C
• 折射率: 1.711

生物活性

• 描述: Ethimidine (Aethimidinum) 可以降低先前移植肉瘤或癌细胞的大鼠血清中的游离 SH (巯基)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. G I Kulik, et al. Effect of alkylating antitumour preparations on the blood serum SH-groups under clinical and experimental conditions. Vrach Delo. 1966 Sep:9:87-9.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UV7065000 CHEMICAL NAME : Pyrimidine, 2,4-bis(1-aziridinyl)-6-chloro- CAS REGISTRY NUMBER : 2482-80-6 BEILSTEIN REFERENCE NO. : 0188373 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C8-H9-Cl-N4 MOLECULAR WEIGHT : 196.66 WISWESSER LINE NOTATION : T6N CNJ DG B- AT3NTJ& F- AT3NTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1350 ug/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : Mutation test systems - not otherwise specified MUTATION DATA TEST SYSTEM : Rodent - rat DOSE/DURATION : 2500 ug/kg REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,357,1951

安全

• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%