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Product Name: Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-
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2482-80-6

2482-80-6 structure

2482-80-6 structure

Name: Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-
Chemical Name: 2,4-bis(aziridin-1-yl)-6-chloropyrimidine
CAS Number: 2482-80-6
Molecular Formula: C₈H₉ClN₄
Molecular Weight: 196.63700
Catalog: Research Areas Cancer
Create Date: 2017-03-07 08:33:40
Modify Date: 2024-04-01 17:37:29
Ethimidine (Aethimidinum) can reduce the blood serum free SH (sulfhydryl) in in rats previously transplanted with sarcoma or carcinoma cells[1].

Name	2,4-bis(aziridin-1-yl)-6-chloropyrimidine
Synonyms	2,4-Bis-aziridin-1-yl-6-chlor-pyrimidin Ethymidine Aethimidinum 2,4-Diethylenimino-6-chloropyrimidine 2,4-bis-aziridin-1-yl-6-chloro-pyrimidine Etimidin Ethimidine 2,6-Diethylenimino-4-chloropyrimidine Aethimidinium

Description	Ethimidine (Aethimidinum) can reduce the blood serum free SH (sulfhydryl) in in rats previously transplanted with sarcoma or carcinoma cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. G I Kulik, et al. Effect of alkylating antitumour preparations on the blood serum SH-groups under clinical and experimental conditions. Vrach Delo. 1966 Sep:9:87-9.

Density	1.561g/cm3
Boiling Point	410.4ºC at 760mmHg
Molecular Formula	C₈H₉ClN₄
Molecular Weight	196.63700
Flash Point	202ºC
Exact Mass	196.05200
PSA	31.80000
LogP	0.90000
Vapour Pressure	6.06E-07mmHg at 25°C
Index of Refraction	1.711

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV7065000

CHEMICAL NAME :: Pyrimidine, 2,4-bis(1-aziridinyl)-6-chloro-

CAS REGISTRY NUMBER :: 2482-80-6

BEILSTEIN REFERENCE NO. :: 0188373

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C8-H9-Cl-N4

MOLECULAR WEIGHT :: 196.66

WISWESSER LINE NOTATION :: T6N CNJ DG B- AT3NTJ& F- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1350 ug/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 2500 ug/kg

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,357,1951

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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