Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-

Modify Date: 2024-04-01 17:37:29

Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro- Structure
Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro- structure
 Common Name Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-
CAS Number 2482-80-6 Molecular Weight 196.63700
Density 1.561g/cm3 Boiling Point 410.4ºC at 760mmHg
Molecular Formula C8H9ClN4 Melting Point N/A
MSDS N/A Flash Point 202ºC

 Use of Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-


Ethimidine (Aethimidinum) can reduce the blood serum free SH (sulfhydryl) in in rats previously transplanted with sarcoma or carcinoma cells[1].

 Names

Name 2,4-bis(aziridin-1-yl)-6-chloropyrimidine
Synonym More Synonyms

  Biological Activity

Description Ethimidine (Aethimidinum) can reduce the blood serum free SH (sulfhydryl) in in rats previously transplanted with sarcoma or carcinoma cells[1].
Related Catalog
References

[1]. G I Kulik, et al. Effect of alkylating antitumour preparations on the blood serum SH-groups under clinical and experimental conditions. Vrach Delo. 1966 Sep:9:87-9.  

 Chemical & Physical Properties

Density 1.561g/cm3
Boiling Point 410.4ºC at 760mmHg
Molecular Formula C8H9ClN4
Molecular Weight 196.63700
Flash Point 202ºC
Exact Mass 196.05200
PSA 31.80000
LogP 0.90000
Vapour Pressure 6.06E-07mmHg at 25°C
Index of Refraction 1.711

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV7065000
CHEMICAL NAME :
Pyrimidine, 2,4-bis(1-aziridinyl)-6-chloro-
CAS REGISTRY NUMBER :
2482-80-6
BEILSTEIN REFERENCE NO. :
0188373
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C8-H9-Cl-N4
MOLECULAR WEIGHT :
196.66
WISWESSER LINE NOTATION :
T6N CNJ DG B- AT3NTJ& F- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1350 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
2500 ug/kg
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,357,1951

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2,4-Bis-aziridin-1-yl-6-chlor-pyrimidin
Ethymidine
Aethimidinum
2,4-Diethylenimino-6-chloropyrimidine
2,4-bis-aziridin-1-yl-6-chloro-pyrimidine
Etimidin
Ethimidine
2,6-Diethylenimino-4-chloropyrimidine
Aethimidinium
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Chemsrc provides CAS#:2482-80-6 MSDS, density, melting point, boiling point, structure, etc. Its name is Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro->> amp version: Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-

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