737-76-8

• 常用中文名：Adenosine,5'-azido-5'-deoxy-
• 常用英文名：Adenosine,5'-azido-5'-deoxy-
• CAS号：737-76-8
• 分子式：C₁₀H₁₂N₈O₃
• 分子量：292.25
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2016-01-21 06:18:05
• 更新时间：2024-02-19 13:06:03
• 5′-叠氮基-5′-脱氧腺苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 英文名: 2-(6-aminopurin-9-yl)-5-(azidomethyl)oxolane-3,4-diol
• 英文别名: 5'-Azido-5'-desoxy-adenosin; 5'-azido-5'-deoxyAdo; 5'-Deoxy-5'-azido-adenosin; 5'-Deoxy-5'-azidoadenosine; 5'-Azidoadenosine; 5'-azido-5'-deoxyadenosine

物化性质

• 分子式: C₁₀H₁₂N₈O₃
• 分子量: 292.25
• 精确质量: 292.10300
• PSA: 169.06000

生物活性

• 描述: 5′-叠氮基-5′-脱氧腺苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

合成路线

662131-88-6 ~44% 737-76-8

文献：Ciuffreda, Pierangela; Loseto, Angela; Alessandrini, Laura; Terraneo, Giancarlo; Santaniello, Enzo European Journal of Organic Chemistry, 2003 , # 24 p. 4748 - 4751

892-48-8 ~% 737-76-8

文献：Peterson, Matt A.; Oliveira, Marcelio; Christiansen, Michael A.; Cutler, Christopher E. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6775 - 6779

34245-48-2 ~% 737-76-8

文献：Comstock, Lindsay R; Rajski, Scott R Tetrahedron, 2002 , vol. 58, # 30 p. 6019 - 6026

57610-04-5 ~% 737-76-8

文献：Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459

68144-26-3 ~% 737-76-8

文献：Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459

40653-96-1 ~% 737-76-8

文献：Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459

4546-55-8 ~% 737-76-8

文献：Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459

362-75-4 ~% 737-76-8

文献：Comstock, Lindsay R; Rajski, Scott R Tetrahedron, 2002 , vol. 58, # 30 p. 6019 - 6026

58-61-7 ~% 737-76-8

文献：Shelton, Jadd R.; Burt, Scott R.; Peterson, Matt A. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1484 - 1487

上下游产品

上游产品  8
662131-88-6 892-48-8 34245-48-2 57610-04-5
68144-26-3 4546-55-8 362-75-4 58-61-7
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18945-38-5 14365-44-7