52867-74-0

• 常用中文名：佐洛哌隆
• 常用英文名：Zoloperone
• CAS号：52867-74-0
• 分子式：C₂₂H₂₄FN₃O₃
• 分子量：397.44300
• 发布时间：2018-08-12 16:26:30
• 更新时间：2024-01-10 17:10:05

名称

• 中文名: 佐洛哌隆
• 英文名: 4-(4-fluorophenyl)-5-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-3H-1,3-oxazol-2-one
• 英文别名: 2(3H)-Oxazolone,4-(4-fluorophenyl)-5-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl); Zoloperonum [INN-Latin]; Zoloperone; 4-(4-fluoro-phenyl)-5-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3H-oxazol-2-one; 4-(p-Fluorophenyl)-5-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-4-oxazolin-2-one; LR 511; Zoloperona [INN-Spanish]; 4-(4-Fluorophenyl)-5-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-2(3H)-oxazolone; 4-p-fluorophenyl-5-N-(N'-o-methoxy-phenyl)piperazinoethyl-4-oxazolin-2-one; 2-oxazolol,4-(4-fluorophenyl)-5-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]

物化性质

• 密度: 1.24g/cm3
• 分子式: C₂₂H₂₄FN₃O₃
• 分子量: 397.44300
• 精确质量: 397.18000
• PSA: 61.71000
• LogP: 3.15020
• 折射率: 1.582

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RQ5832380 CHEMICAL NAME : 2(3H)-Oxazolone, 4-(4-fluorophenyl)-5-(2-(4-(2-methoxyphenyl)-1-pipera zinyl)ethyl)- CAS REGISTRY NUMBER : 52867-74-0 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C22-H24-F-N3-O3 MOLECULAR WEIGHT : 397.49 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 15,485,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 15,485,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 15,485,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 32,2241,1989 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 15,485,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 15,485,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 15,485,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 15,485,1977

合成路线

590-28-3 51037-51-5 ~% 52867-74-0

文献：Cascio, Giuseppe; Manghisi, Elso; Fregnan, Giancarlo Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2241 - 2247

75-44-5 51037-51-5 ~% 52867-74-0

文献：Cascio, Giuseppe; Manghisi, Elso; Fregnan, Giancarlo Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2241 - 2247

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